Roller-Induced Bundling of Long Silver Nanowire Networks for Strong Interfacial Adhesion, Highly Flexible, Transparent Conductive Electrodes.

Silver nanowires (AgNWs) have been the most promising electrode materials for fabrication of flexible transparent touch panel, displays and many other electronics because of their excellent electrical properties, cost effectiveness, synthesis scalability, and suitability for mass production. Although a few literature reports have described the use of short Ag NWs in fabrication of randomly oriented Ag NW network-based electrode, their electrical conductivities are still far lower than that of Ag films. So far, no any literature report was able to provide any simple solution to fabrication of large-area and mass-manufactural ability to address the issues, such as, conductivity, transparency, electrical current withstand, bending stability, and interfacial adhesion.

A disposable breath sensing tube with on-tube single-nanowire sensor array for on-site detection of exhaled breath biomarkers.

This paper presents a novel disposable breath-sensing tube with an on-tube single-nanowire (NW) sensor array for noninvasive, simple, and on-site detection of exhaled breath biomarkers. Although various noninvasive detection methods for lung cancer biomarkers in breath samples exist, they are unsuitable for self-diagnostics and immediate detection because they entail complicated handling procedures and are time intensive. In this study, we simulated, fabricated, and characterized disposable nanosensors by using single TiO and Ag NWs in flexible plastic tubes.

Handheld analyzer with on-chip molecularly-imprinted biosensors for electrical detection of propofol in plasma samples.

This paper proposes a novel handheld analyzer with disposable lab-on-a-chip technology for the electrical detection of the anesthetic propofol in human plasma samples for clinical diagnoses. The developed on-chip biosensors are based on the conduction of molecularly imprinted polymers (MIPs) that employ label-free electrical detection techniques. Propofol in total intravenous anesthesia is widely used with a target-controlled infusion system.

A disposable emulsion droplet generation lab chips driven by vacuum module for manipulation of blood cells.

This paper presents a novel disposable emulsion droplet generation lab chip driven by vacuum module for monodisperse emulsions generation and blood cell encapsulation. Emulsion droplet is a powerful tool in miniaturized analysis systems for high throughput processing. It shows great potential in chemical and biological reactions like speeding up the reaction and reducing the cost of reagents.

Point-of-care protein sensing platform based on immuno-like membrane with molecularly-aligned nanocavities.

This paper presents the ability of the novel point-of-care protein sensing platform based on immune-like polymer membrane to separate and sense target analytes in human serum samples using the molecularly-aligned nanocavities. The separation performance of the developed membrane, which is substantially affected by surface chemistry and physics, can be enhanced by alignment of the template molecules. The developed biomimetic membrane with aligned molecular nanocavities can be synthesized and integrated with microfluidic biochips as point-of-care sensing platforms.

Enhanced anesthetic propofol biochips by modifying molecularly imprinted nanocavities of biosensors.

This paper presents enhanced performance of anesthetic propofol biosensors by modifying molecularly imprinted nanocavities of biosensors. In this work, the relationship between molecularly imprinted nanocavities and performance of molecularly imprinted polymer (MIP) films is investigated. The morphological control of imprinted nanocavities on molecularly imprinted biosensors is done by adjusting polymer composition and polymerization process.

A microfluidic chip platform with electrochemical carbon nanotube electrodes for pre-clinical evaluation of antibiotics nanocapsules.

This paper presents a microfluidic chip platform with electrochemical carbon nanotube electrodes for preclinical evaluation of antibiotics nanocapsules. Currently, there has been an increasing interest in the development of nanocapsules for drug delivery applications for localized treatments of diseases. So far, the methods to detect antibiotics are liquid chromatography (LC), high performance liquid chromatography (HPLC), mass spectroscopy (MS).

A disposable microfluidic biochip with on-chip molecularly imprinted biosensors for optical detection of anesthetic propofol.

This paper presents a disposable microfluidic biochip with on-chip molecularly imprinted biosensors for optical detection of anesthetic propofol. So far, the methods to detect anesthetic propofol in hospitals are liquid chromatography (LC), high-performance liquid chromatography (HPLC), and gas chromatography-mass spectroscopy (GC-MS). These conventional instruments are bulky, expensive, and not ease of access.

Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters.

This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-a-chip using fully integrated plastic microfluidic components, which has the sampling/identifying capability to make fast and reliable measurements of metabolic parameters from human whole blood. A smart and functional lab-on-a-chip cartridge, which incorporates a full on-chip auto-calibration function for in the field applications, has been developed, and then fully characterized using a portable analyzer (3 (1/4)''x 5''x 1'') with multi-analyte detection capability. In addition, several new approaches in realizing smart and functional lab-on-a-chips on polymer have been adopted, which include the pinch valve for automatic fluidic sealing, a by-pass channel as the sampling indicator, and a robust connector design for long analyzer lifetimes.

A novel in-plane passive microfluidic mixer with modified Tesla structures.

An innovative in-plane passive micromixer using modified Tesla structures, which are used as passive valves, has been designed, simulated, fabricated and successfully characterized in this paper. Simulation and experimental results of the developed novel micromixer have shown excellent mixing performance over a wide range of flow conditions in the micro scale. The micromixer realized in this work has achieved even better mixing performance at a higher flow rate, and its pressure drop is less than 10 KPa at the flow rate of 100 microl min(-1).

A functional on-chip pressure generator using solid chemical propellant for disposable lab-on-a-chip.

This paper presents a functional on-chip pressure generator that utilizes chemical energy from a solid chemical propellant to perform fluidic delivery in applications of plastic-based disposable biochips or lab-on-a-chip systems. In this functional on-chip pressure generator, azobis-isobutyronitrile (AIBN) as the solid chemical propellant is deposited on a microheater using a screen-printing technique, which can heat the AIBN at 70 degrees C to produce nitrogen gas. The output pressure of nitrogen gas, generated from the solid chemical propellant, is adjustable to a desired pressure by controlling the input power of the heater.