Synthesis and cytotoxic activity of madecassic acid-silybin conjugate compounds in liver cancer cells.

A series of 14 conjugates of 2α,3β,23-triacetyl-madecassic acid and silybin were designed and synthesized. The madecassic acid unit was linked to silybin either directly at position C-7 or C-3; or through an amino acid linker (glycine, β-alanine, or 11-aminoundecanoic acid) at position C-3. The conjugates were tested for their cytotoxic effect on HepG2 cells using the MTT assay.

Metabolites from (VTCC43181) and Their Inhibition of ClpC1 Protein.

Tuberculosis is one of the most common infectious diseases in the world, caused by . The outbreak of multiple drug-resistant tuberculosis has become a major challenge to prevent this disease worldwide. ClpC1 is a Clp ATPase protein of , functioning as a chaperon when combined with the Clp complex.

Two new glycosides, farnesyl pentaglycoside and oleanane triglycoside from , a mangrove plant collected from Thua Thien-Hue province, Vietnam.

Phytochemical investigation of the leaves of led to the isolation of two new glycosides, lepisantheside A () and lepisantheside B (), together with two known compounds acutoside A () and 3-O-[-D-xylopyranosyl-(1→3)--D-glucopyranosyl-]-oleanolic acid (. Their structures were elucidated by means of spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated.