Development of a Japanese Scale that Evaluates the Level of Nursing Support Provided to Patients for Decision-Making in Cancer Clinical Trials.

Clinical nurses need learning programs that are useful in nursing support for patients' decision-making (NSPDM) regarding cancer clinical trials (CCTs). The usefulness of the learning program can be evaluated if the practices of NSPDM before and after participation in the learning program can be compared. We developed a scale to measure the level of self-assessed NSPDM regarding participation in a CCT.

Mechanistic study on the reaction of pinB-BMes with alkynes based on experimental investigation and DFT calculations: gradual change of mechanism depending on the substituent.

Transition metal-free direct and base-catalyzed 1,2-diborations of arylacetylenes using pinB-BMes provided a /-isomeric mixture of diborylalkenes. The kinetic analysis showed that the reaction rate and isomer ratio were affected by reaction conditions and substituents on the aryl ring. DFT calculations indicated that direct addition proceeded the interaction of acetylene-π with the BMes fragment.

Direct and Base-Catalyzed Diboration of Alkynes Using the Unsymmetrical Diborane(4), pinB-BMes2.

In the absence of transition metal catalysts, the unsymmetrical diborane(4), pinB-BMes2, reacted with alkynes to afford diborylalkenes. The isomer ratio of the products could be controlled via temperature, solvent, and additive(s). A reaction mechanism was proposed on the basis of two isolated intermediates, and this reaction could furthermore be applied to synthesize a luminescent molecule.