Publications by Chie Kise

Publications by authors named "Chie Kise"

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NSC-3852 synergistically enhances the cytotoxicity of olaparib in oral squamous cell carcinoma.

Yuka Sasaki Takuma Inouchi Chie Kise Ryusuke Nakatsuka Amane Inoue

Biochem Biophys Res Commun

January 2025

The PARP inhibitor olaparib is an anti-cancer agent based on synthetic lethality that targets poly (ADP-ribose) polymerases. It is used as a therapeutic agent for breast, ovarian, pancreatic, and prostate cancers carrying BRCA1/2 mutations that cause deficiency in homologous recombination. In recent years, acquired resistance to PARP inhibitors has become a clinical problem in PARP inhibitor-treated patients.

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