Publications by authors named "Chie Hisada"
Purpose: Prenatal stress affects the hippocampal structure and function in pups. Maternal chewing ameliorates hippocampus-dependent cognitive impairments induced by prenatal stress. In this study, we investigated hippocampal microglia-mediated neuroinflammation in pups of dams exposed to prenatal stress with or without chewing during gestation.
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- The study investigates how maternal chewing may influence the negative effects of prenatal stress on the behavior and brain chemistry of mouse offspring.
- Pregnant mice were subjected to stress through restraint and some were given a chewing object; their offspring were later tested for behavioral changes and brain protein levels.
- Results showed that maternal chewing helped reduce anxiety and cognitive impairments in pups, suggesting it positively impacts brain health and serotonin levels related to prenatal stress.