Changes in thyroid function after bone marrow transplant in young patients.

Background: Changes in thyroid function among young patients who received bone marrow transplantation (BMT) were evaluated.

Methods: The study included 91 patients (50 males) who underwent BMT from 1985 to 1995 at the age of 0.6-21 years.

Persistence of mild hyperthyrotropinemia after discontinuation of three-year course of low-dose L-thyroxine therapy in infants with borderline hypothyroidism.

Treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia with normothyroxinemia) has not been established. In this study, changes in thyroid function after discontinuation of low-dose L-thyroxine (L-T4) supplement in infants with the condition were evaluated. Fourteen infants with hyperthyrotropinemia at neonatal screening had repeated hyperthyrotropinemia (> 8 mU/L) with normothyroxinemia.