Publications by authors named "Chidimma Kalu"
Article Synopsis
- The study investigates the effects of dietary n-3 polyunsaturated fatty acids (EPA and DHA) on women with estrogen receptor and progesterone receptor-negative (ERPR-) breast cancer over a 12-month period.
- Participants received either 1g/d or 5g/d of EPA+DHA supplementation, with results indicating that the higher dosage was more effective in increasing n-3 PUFAs and reducing plasma triglycerides.
- The research also identified distinct DNA methylation patterns in adipose tissue linked to the 5g/d dosage, suggesting significant metabolic and molecular changes associated with higher n-3 fatty acid intake.
Purpose: Aromatase inhibitor (AI) therapy reduces risk of recurrence and death for postmenopausal women with breast cancer (BC); however, AI-induced arthralgia (AIIA) can lead to discontinuation of treatment. Curcumin, a bioactive polyphenolic substance, may help ameliorate inflammation-related conditions including osteoarthritis and pain.
Methods: We conducted a multisite randomized placebo-controlled, double-blind pilot trial (Alliance A22_Pilot9) to evaluate the effects of nanoemulsion curcumin (NEC, 200 mg/day) in postmenopausal women experiencing AIIA for ≥ 3 months.
Background: The cause and treatment of Kienböck disease is controversial. No treatment algorithm has been accepted. We surveyed US hand surgeons to determine trends and attitudes regarding the treatment of Kienböck disease.
View Article and Find Full Text PDFThe MLL-partial tandem duplication (PTD) associates with high-risk cytogenetically normal acute myeloid leukemia (AML). Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML. However, mice expressing either Mll-PTD or Flt3-ITD do not develop AML, suggesting that 2 mutations are necessary for the AML phenotype.
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