Cancer-associated thrombosis: what is new?

Purpose Of Review: The life expectancy of patients suffering from thrombosis associated with cancer has improved significantly, making them a chronic disease. Patients with thrombosis and cancer are fragile. Treated with anticoagulants, they remain at risk of complications.

Diagnostic Approach for Venous Thromboembolism in Cancer Patients.

Venous thromboembolic disease (VTE) is a common complication in cancer patients. The currently recommended VTE diagnostic approach involves a step-by-step algorithm, which is based on the assessment of clinical probability, D-dimer measurement, and/or diagnostic imaging. While this diagnostic strategy is well validated and efficient in the noncancer population, its use in cancer patients is less satisfactory.

Granulosa tumor: two spontaneous pregnancies after combined medico-surgical treatment: case report and review of the literature.

Background: Granulosa tumor is a rare tumor that arises from the mesenchyme and the sexual cord of the ovary. The prognosis is generally excellent, and treatment is mainly based on surgery, followed by chemotherapy depending on the extension of the disease. However, "the obstetrical prognosis" is compromised.

Metformin-Associated Lactic Acidosis in a Diabetic Patient with Normal Kidney Function and Occult Cirrhosis.

Background: Lactic acidosis is a well-known complication of metformin accumulation in diabetic patients with kidney failure. However, it is not usual to raise the diagnosis of metformin-associated lactic acidosis when patients have normal kidney function. The causes of metformin-induced high lactate include the accumulation of normal doses of metformin in chronic kidney disease, an overdose of this drug without kidney failure, or an increase in lactate production due to the inhibition of liver gluconeogenesis.

Prevalence and Associated Factors of Social Anxiety Among Lebanese Adolescents.

To determine the prevalence of social anxiety among Lebanese adolescents and assess its association with bullying and child abuse. This cross-sectional investigation conducted between January and May 2019 recruited 1,810 adolescents aged 14 to 17 years selected randomly from private schools from all Lebanese governates (Beirut, Mount Lebanon, North, South, and Bekaa). Participants completed a questionnaire that included items from the Liebowitz Social Anxiety Scale, the Childhood Abuse Self-Report Scale, and the Illinois Bully Scale.

Non-Flammable Sodium Asymmetric Imide Salt-Based Deep Eutectic Solvent for Supercapacitor Applications.

This study reports two deep eutectic solvents (DESs) based on alkaline imide salts with asymmetric anions as functional electrolytes for supercapacitor (SC) application. The eutectic mixture of sodium (fluorosulfonyl) (trifluoromethanesulfonyl) imide (NaFTFSI) or sodium cyano-trifluoromethanesulfonyl imide (NaTFSICN) with ethylene carbonate (EC) delivers a non-flammable and stable liquid. The eutectic diagrams of the electrolytes directed to an optimal composition (w =0.

Role of FTFSI Anion Asymmetry on Physical Properties of AFTFSI (A=Li, Na and K) Based Electrolytes and Consequences on Supercapacitor Application.

This study compares the physicochemical properties of six electrolytes comprising of three salts: LiFTFSI, NaFTFSI and KFTFSI in two solvent mixtures, the binary (3EC/7EMC) and the ternary (EC/PC/3DMC). The transport properties (conductivity, viscosity) as a function of temperature and concentration were modeled using the extended Jones-Dole-Kaminsky equation, the Arrhenius model, and the Eyring theory of transition state for activated complexes. Results are discussed in terms of ionicity, solvation shell, and cross-interactions between electrolyte components.

Pesticide-induced multigenerational effects on amphibian reproduction and metabolism.

Underlying drivers of species extinctions need to be better understood for effective conservation of biodiversity. Nearly half of all amphibian species are at risk of extinction, and pollution may be a significant threat as seasonal high-level agrochemical use overlaps with critical windows of larval development. The potential of environmental chemicals to reduce the fitness of future generations may have profound ecological and evolutionary implications.

Composition's effect of Origanum Syriacum essential oils in the antimicrobial activities for the treatment of denture stomatitis.

This research has several purposes: First to assess the bacterial and fungal minimum inhibitory concentration of Origanum Syriacum essential oil. Second to quantify its bactericidal and fungicidal minimal concentration against S. aureus, S.

Long-Term Treatment of Cancer-Associated Thrombosis (CAT) Beyond 6 Months in the Medical Practice: USCAT, a 432-Patient Retrospective Non-Interventional Study.

Background: extended anticoagulant therapy beyond the initial 6 months is suggested in patients with cancer-associated thrombosis (CAT) and active cancer. Few data are available on patient management and outcomes on the period between 6 and 12 months after the venous thromboembolism (VTE) event.

Objectives: our objective was to document patient management and outcomes beyond 6 months and up to 12 months in CAT patients initially treated for 6 months with tinzaparin.

Patients experience of living with cancer associated thrombosis in France (Le PELICAN).

Introduction: Previous research in the United Kingdom and Spain has identified several areas of unmet clinical and support need for cancer patients diagnosed with cancer associated thrombosis (CAT). These included lack of information, which was directly associated with distress. Appropriate information has been shown to improve tolerance and compliance with self-injecting low molecular weight heparin (LMWH).

Contribution of capsaicin-sensitive innervation to the continuous eruption of the rat mandibular incisors.

A major component of tooth innervation is made of capsaicin-sensitive primary afferents (CSPA). These fibers play a key role in tooth pain and inflammation; little is known, however, about the role of CSPA in tooth eruption. The aim of this study was to examine the role of the capsaicin-sensitive afferents in the process of eruption of intact rat incisors.

Modulation of incisor eruption in rats by sympathetic efferents.

Introduction: Intact neural supply is necessary for tooth eruption. Sympathetic denervation accelerates or decelerates the eruption rate depending on the tooth condition (intact or injured). The aim of this study is to reexamine the role of the sympathetic innervation, through the observation of the effects of pre or post ganglionic chemical sympathectomy on the eruption of intact rat incisors.

Fit of pressed crowns fabricated from two CAD-CAM wax pattern process plans: A comparative in vitro study.

Statement Of Problem: Subtractive and additive computer-aided design and computer-aided manufacturing (CAD-CAM) wax pattern processing are 2 methods of fabricating a pressed ceramic crown. Whether a subtractive milled wax pattern or a pattern from the micro-stereolithography additive process produces lithium disilicate crowns with better marginal and internal fit is unclear.

Materials And Methods: Ten silicone impressions were made for a prepared canine tooth.

The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site.

Background: We hypothesized that the clinical course of venous thromboembolism in patients with active cancer may differ according to the specificities of primary tumor site.

Aim And Methods: We used data from RIETE (international registry of patients with venous thromboembolism) to compare the clinical venous thromboembolism-related outcomes during the course of anticoagulation in patients with one of the 4 more frequent cancers (breast, prostate, colorectal, or lung cancer).

Results: As of September 2014, 3947 cancer patients were recruited, of whom 938 had breast, 629 prostate, 1189 colorectal, and 1191 lung cancer.

US Medical Schools' Awareness of Their Students Who Smoke, Cessation Programs Available, and the Potential Impact on Residency Match.

Introduction: Hospital systems are adopting strict nicotine-free policies excluding hiring individuals who smoke, including residents for graduate medical training. This study was conducted to (1) determine medical schools' awareness of these policies, (2) awareness of their students' smoking behaviors, and (3) the smoking cessation programs that they provide.

Methods: A survey was developed to learn about the smoking policies of medical schools in the United States: how school leadership estimates smoking prevalence among their students, what those estimates are, and what programs are in place to help students quit smoking.

Factors influencing adherence to clinical guidelines in the management of cancer-associated thrombosis.

International academic and regulatory guidelines consistently recommend the long-term use of low-molecular-weight heparins (LMWHs) as the standard for the treatment of cancer-associated thrombosis (CAT). However, both physicians and patients are reluctant to follow established guidelines. Insufficient compliance with treatment recommendations among care physicians represents a loss of opportunity for patients at very high risk of recurrence of venous thromboembolism (VTE) and death.

PO-47 - Microparticles derived from ovarian cancer cell line contained genomic and biologically active proteins, including tissue factor involved in coagulation.

Introduction: The microparticles (MPs) are sized vesicles of less than 1 μm, from different cell types upon activation or subsequent to apoptosis. They are involved in the thrombotic process, particularly in cancer. The role of MPs in ovarian cancer and their involvement in thrombosis being poorly understood.

PO-23 - Expression of heparanase in cancer as biomarker of malignancies: overexpression in an aggressive, poor survival gastric cancer "gastric signet ring cell carcinoma" compared with that of other gastric cancers.

Introduction: Gastric signet ring cell carcinoma (GSRC) is a distinct entity among of other gastric cancer. With unknown etiopathology, their incidence is increasing and it presents a low sensitivity to chemotherapy.

Aim: Here, we studied the expression of the heparanase (HPA) in cancer tissues from GSRC patients and several cancer cell lines.

Adherence to treatment guidelines for cancer-associated thrombosis: a French hospital-based cohort study.

Purpose: French 2008 treatment guidelines recommend low-molecular-weight heparins (LMWH) for the treatment of cancer-associated thrombosis (CAT) with treatment duration of at least 3 months and up to 6 months and beyond if cancer remains active. Our aim was to assess adherence to guidelines in hospital clinical practice.

Methods: The French hospital database (PMSI) was used to identify patients with CAT admitted to three hospitals of the Paris region to be included in a retrospective cohort study.

Marginal and internal fit of pressed ceramic crowns made from conventional and computer-aided design and computer-aided manufacturing wax patterns: An in vitro comparison.

Statement Of Problem: To our knowledge, no studies have evaluated the influence of the wax fabrication technique on the internal adaptation and marginal accuracy of pressed ceramic single crowns.

Purpose: The purpose of this in vitro study was to compare the marginal and internal fit of a lithium disilicate crown fabricated either from conventional waxing or from a subtractive milled wax pattern.

Material And Methods: Ten silicone impressions were made for a maxillary canine prepared to receive a complete crown.

Considerations for Altering Preparation Designs of Porcelain Inlay/Onlay Restorations for Nonvital Teeth.

Purpose: The aim of this study was to compare all ceramic inlay/onlay survival rates in vital and nonvital teeth having the same cavity design. Filling the pulp chamber with ceramic materials or not was also discussed.

Materials And Methods: Ceramic class II inlays/onlays were made on 11 premolars and 30 molars: 14 vital, 27 endodontically treated.

Ambulatory continuous interscalene blocks for cancer pain.

Continuous peripheral nerve blocks are used in the management of pain following surgical procedures. They can also be used in patients with cancer-related pain, to improve sleep quality, reduce opioid requirements and their side effects. We describe two cancer patients in whom interscalene brachial plexus catheters were used on an outpatient basis, allowing them to travel, decrease their opioid use, and improve their ability to perform routine activities.