Publications by authors named "Chidchanok Chornkrathok"
Article Synopsis
- Intrahepatic cholangiocarcinoma (iCCA) is a dangerous cancer characterized by a high presence of cancer stem-like cells (CSCs), but understanding the weaknesses of these CSCs is still a mystery.
- A 3D tumorsphere culture system was used to identify key kinase inhibitors affecting the viability of these CSCs; it was found that most of these inhibitors targeted the IGF-1R/PI3K/AKT pathway.
- Silencing the IGF-1R gene in multiple iCCA cell lines led to reduced cell growth and tumorsphere formation, suggesting that IGF-1R is essential for the survival of CSCs in iCCA, making it a promising target for treatment and diagnosis
Primary liver cancer (PLC), which includes intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC), has the highest incidence of all cancer types in Thailand. Known etiological factors, such as viral hepatitis and chronic liver disease do not fully account for the country's unusually high incidence. However, the gut-liver axis, which contributes to carcinogenesis and disease progression, is influenced by the gut microbiome.
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