SGLT2i as a First-line Antihyperglycemic in the Management of Type 2 Diabetes in the Context of Indians: A Systematic Review and Consensus.

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been used for almost a decade and have proven to be effective not only in managing Type 2 diabetes (T2D), but their cardio and renal protective features make them very useful in managing patients with risk of multiple comorbidities. This systematic review was undertaken by the authors because there is no evidence currently available in India that has studied the suitability of SGLT2i as a first-line agent in patients newly diagnosed with T2D in India.

Materials And Methods: First, literature was searched to identify features that are considered important when deciding on a first-line agent for managing T2D.

Malignant adnexal tumour of the shoulder-a rare case report.

Malignant adnexal tumours are a very rare and highly aggressive primary skin neoplasms. Among them, malignant hidradenocarcinoma is a particularly aggressive tumour that arises from the intradermal duct of eccrine sweat glands. It more commonly arises and rarely from a pre-existing hidradenoma.

Biomass-derived carbon boosted catalytic properties of tungsten-based nanohybrids for accelerating the triiodide reduction in dye-sensitized solar cells.

Manganese tungstate (MnWO), zinc tungstate (ZnWO), and copper tungstate (CuWO) embedded biomass-derived carbon (MWO-C, ZWO-C, CWO-C) was synthesized by hydrothermal treatment and investigated as counter electrode (CE) catalysts to test electrochemical activity. Biomass-derived carbon was used as the shape controlling agent, which changed the morphology of MWO from spherical to spindle-like. Owing to the synergistic effect between tungsten-based bimetal oxides and biomass-derived carbon, the MWO-C, ZWO-C, and CWO-C catalysts exhibited enhanced electrochemical performance in dye-sensitized solar cells (DSSCs) system.

Profile and Outcome of Pediatric Brain Tumors - Experience from a Tertiary Care Pediatric Oncology Unit in South India.

Context: Tumors of the central nervous system (CNS) constitute the second most common pediatric cancers. Unlike leukemia, management of CNS tumors requires a good multidisciplinary team. Higher rates of treatment abandonment are documented in view of complexity of the treatment with long duration, involving neurosurgery, radiation, chemotherapy, and high cost of treatment.

Transcriptome profiling reveals higher vertebrate orthologous of intra-cytoplasmic pattern recognition receptors in grey bamboo shark.

From an immunologist perspective, sharks are an important group of jawed cartilaginous fishes and survey of the public database revealed a great gap in availability of large-scale sequence data for the group of Chondrichthyans the elasmobranchs. In an attempt to bridge this deficit we generated the transcriptome from the spleen and kidney tissues (a total of 1,606,172 transcripts) of the shark, Chiloscyllium griseum using the Illumina HiSeq2000 platform. With a cut off of > = 300 bp and an expression value of >1RPKM we used 43,385 transcripts for BLASTX analysis which revealed 17,548 transcripts matching to the NCBI nr database with an E-value of < = 10(-5) and similarity score of 40%.

Differential detection of avian oncogenic viruses in poultry layer farms and Turkeys by use of multiplex PCR.

Avian oncogenic viruses include Marek's disease virus (MDV), a highly contagious herpesvirus, as well as retroviruses such as avian leukosis virus (ALV) subgroups A to J and reticuloendotheliosis virus (REV). In this study, we examined the incidence of these viruses in suspected samples collected from poultry layer farms of South India, mainly in the Namakkal district of Tamil Nadu, a highly dense poultry-growing area in India. The histopathology-positive tissue sections were identified and further confirmed by immunohistochemistry using virus-specific antibodies.

Head injuries in children resulting from the fall of television.

Case records of children admitted with head injury due to TV fall in a pediatric tertiary care hospital in Chennai, during March 2007-February 2008 were analysed retrospectively. Out of the 11 children admitted 6 (54%) were in 1-2 yr age group. Bleeding from the ear, nose and throat was the commonest, finding followed by a skull fracture, seen on imaging studies.

Histological and immunohistochemical characterization of AT/RT: a report of 15 cases from India.

Atypical teratoid rhabdoid tumor (AT/RT) is a highly malignant embryonal CNS tumor, generally unresponsive to any form of therapy, uniformly fatal within 1 year. We report 15 cases of AT/RT diagnosed at our center over a period of 5 years (2003-08). Tumors were located in different sites of the neuraxis, posterior fossa being the most common (n = 10) followed by cerebral lobes (n = 3).

Teratoid malignant medulloepithelioma of the optic nerve: report of a case and review of the literature.

Medulloepithelioma of the optic nerve is extremely rare and can simulate an optic nerve glioma. We report a histopathologically proven medulloepithelioma in a 3-year-old child with computer tomographic (CT) and magnetic resonance imaging (MRI) features.

Massive triventricular teratoma in an infant.

A massive teratoma occupying both the lateral ventricles and the third ventricle in an infant is reported. The limitations of nomenclature are also indicated.

Aneurysmal bone cyst of the temporal bone.

Aneurysmal bone cysts are uncommon lesions of the bone, which are benign and non-neoplastic in nature. They are commonly seen in the long bones. Their occurrence in the calvarium is rare.

Giant orbital and intracranial xanthogranuloma--a short report.

Xanthogranuloma are known to arise in the paranasal sinus or orbit. They may also arise primarily in the brain. Those arising from the sinuses or orbit might involve the intracranial cavity to some extent.

Intramedullary abscess of the spinal cord.

A case of intramedullary abscess of the spinal cord in a child aged 3 years is reported. Successful outcome depends on early diagnosis and aggressive management.

Natural history of isolated ventricular septal defect in the first five years of life.

Background: Isolated ventricular septal defect (VSD) is the most common congenital heart defect. Incidence, prevalence, and clinical outcomes of VSD have been reported to vary significantly in different geographic areas. Spontaneous closure of VSD, in children, by various methods has been described.

CSF ascites: a rare complication of ventriculoperitoneal shunt surgery.

CSF ascites is a very rare complication of ventriculoperitoneal (VP) shunt procedure. No definite explanation has been offered for the inability of the peritoneum to absorb the CSF. Two children who underwent VP shunting for hydrocephalus, presented with ascites 3 (1/2) years and 4 months respectively, after the shunt was placed.

Medulloepithelioma of the optic nerve with intradural extension--report of two cases and a review of the literature.

Medulloepithelioma is an uncommon tumour. Among the various sites of origin the optic nerve is rare. We report here two cases of medulloepithelioma of the optic nerve that had extended intradurally into the cranial cavity.

Identical twins with medulloblastoma occurring in infancy.

Familial cerebellar medulloblastomas occurred in monozygotic twin siblings during infancy, and they had a rapid downhill course. Both twins underwent surgery for the tumours. This was followed by chemotherapy in the second twin.

Ventricular myxoma presenting as acute visual loss.

We report a case of left ventricular myxoma with embolization to the left posterior cerebral artery, causing acute visual loss. The tumor was successfully resected and a follow-up echocardiography after 21 months revealed no evidence of tumor recurrence. The patient also had a past history of testicular seminoma.

Meningioma without dural attachment in a child.

A case of posterior cranial fossa meningioma without dural attachment is presented. The patient was 8 years old. The tumour was mostly in the cerebellum and was presumably arising from the telechoroidea.

Non-traumatic intracranial haemorrhage in paediatric age group.

This report describes our experience in eight cases of non traumatic intracranial haemorrhage in paediatric age groups. The causes were varied. The importance of rapid and multidisciplinary approach is detailed.

Familial symptomatic sinus bradycardia: autosomal dominant inheritance.

Symptomatic sinus bradycardia, due to either sick sinus syndrome or vagotonia, can be familial, affecting several members of a family. We report an 18-year-old male patient with palpitations and limited exercise capacity who was noted to have severe sinus bradycardia. His resting heart rate was 40/min, with normal PR and corrected QT intervals, and sinus pauses up to 6 seconds during sleep.

Radiologic abnormalities of the sternum in Turner's syndrome.

Various skeletal abnormalities, including chest deformity, have been reported with Turner's syndrome. We report radiologic findings of the sternum on lateral chest roentgenograms in 15 children and adolescents with Turner's syndrome, whose ages ranged between 2 weeks and 20 years. Eight had associated congenital heart disease (CHD).