Publications by authors named "Chiarelli G"

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

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Background: Previous studies found that Midlife Baseline PSA (MB PSA) predicts the risk of developing lethal prostate cancer (PCa), although the cohorts were homogenous in terms of racial compositions. We aimed to investigate racial disparities in the predictive value of MB PSA for lethal PCa in a diverse, contemporary, North American population.

Methods: Our cohort included White and Black men aged 40-59 years, who underwent MB PSA through our health system.

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Purpose: To assess active surveillance (AS) adherence for prostate cancer (PCa) in a "real-world" clinical practice.

Materials And Methods: We utilized our institutional database which was built by interrogating electronic medical records for all men who got diagnosed with PCa from 1995 to 2022. Our cohort included all patients aged < 76 years, with PCa Gleason Grade (GG) 1 or 2, ≤ cT2c, PSA ≤ 20 ng/ml at diagnosis, enrolled on AS, and with at least one biopsy after diagnosis.

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  • Socio-economic and demographic factors impact prostate cancer (PCa) outcomes, particularly through area deprivation index (ADI) and race in a North-American cohort study.
  • The study followed 134,366 men who had at least one PSA test from 1995 to 2022, categorizing them based on ADI scores tied to their residential areas and analyzing PCa incidence and lethality across different racial groups.
  • Results indicated that men in more deprived areas had lower overall PCa incidence but higher lethality; however, Black men experienced increased incidence and worse outcomes compared to White men across all deprivation levels.
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  • This study evaluated cancer control outcomes in prostate cancer patients with clinically positive nodal involvement, comparing surgery with radiation while considering other causes of death.
  • Researchers analyzed data from the SEER database for patients diagnosed from 2004 to 2017, using advanced statistical methods to adjust for differences in treatment and mortality risk.
  • Findings indicated that, after 10 years, patients treated with radiation had significantly higher cancer-specific mortality rates (27.6%) compared to those treated with surgery (18.1%), highlighting the advantages of surgical intervention.
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A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

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  • - The ATLAS experiment at the LHC conducted a search for long-lived particles (LLPs) using a large dataset (140 fb^{-1}) from proton-proton collisions at 13 TeV, focusing on LLPs with masses from 5 to 55 GeV that decay within the inner detector.
  • - The study considered scenarios where LLPs are produced from exotic Higgs boson decays and models involving axionlike particles (ALPs).
  • - No significant findings above expected background levels were detected, leading to the establishment of upper limits on various production rates involving the Higgs boson and the top quark related to LLPs and ALPs.
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  • Non-Hispanic Black (NHB) men have a higher risk of prostate cancer (PCa) incidence and mortality than Non-Hispanic White (NHW) men, but this study focuses on incidental PCa cases from two North American cohorts.
  • The research analyzed data from SEER (2004-2017) and Henry Ford Health (1995-2022) to compare cancer-specific mortality (CSM) and management of incidental PCa between NHB and NHW men, finding no major pathological differences except for slightly elevated PSA levels in NHB men.
  • Conclusions indicate that both groups had similar survival outcomes, challenging previous beliefs that racial disparities significantly affect prostate cancer mortality after incidental diagnoses.
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  • The study investigates the associated production of Higgs and W bosons, focusing on how the relative signs of the Higgs couplings to W and Z bosons impact the process.
  • Two specific searches were conducted using large amounts of collision data from the LHC to analyze different coupling scenarios: one for opposite-sign couplings and another for same-sign (standard model-like) couplings.
  • The results significantly exclude the opposite-sign coupling hypothesis and set a strict upper limit on the production rate of this process compared to standard model predictions.
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  • - The study investigates the effectiveness of midlife baseline prostate-specific antigen (MB PSA) compared to PSA doubling time (PSADT) and PSA velocity (PSAV) in predicting the risk of developing lethal prostate cancer in men aged 40-59.
  • - A total of 77,594 men with at least two PSA tests and 11,634 men with three tests were analyzed, with data gathered from 1995 to 2019 to determine the occurrence of lethal prostate cancer diagnoses.
  • - Results showed significant associations of both MB PSA and PSADT with lethal prostate cancer risk, indicating that those in the top 10th percentile for MB PSA had a 6.10 times higher hazard of developing lethal cancer while those
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This Letter presents results from a combination of searches for Higgs boson pair production using 126-140  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.

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This Letter presents the first study of the energy dependence of diboson polarization fractions in WZ→ℓνℓ^{'}ℓ^{'}(ℓ,ℓ^{'}=e,μ) production. The dataset used corresponds to an integrated luminosity of 140  fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector. Two fiducial regions with an enhanced presence of events featuring two longitudinally polarized bosons are defined.

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  • Studies show that patients receiving radiation therapy (RT) for prostate cancer (PCa) have a higher risk of dying from causes unrelated to cancer than those who have radical prostatectomy (RP), hinting at poorer overall health in RT patients.
  • Using data from the SEER database, researchers matched RP and RT patients based on their risk of other-cause mortality (OCM) and analyzed the effects on cancer-specific mortality (CSM).
  • Results indicate that for patients with unfavorable-intermediate and high-risk cancer, RP significantly reduced CSM rates compared to RT, while no difference was found in those with favorable-intermediate or low-risk disease.
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Objective: Comparative effectiveness studies comparing trimodal therapy (TMT) to radical cystectomy (RC) are typically hindered by selection bias where TMT is usually reserved to patients with poor overall health status. We developed a novel approach by matching patients based on their calculated other-cause mortality (OCM) risk. Using this homogeneous cohort, we tested the impact of TMT vs RC on cancer-specific mortality (CSM).

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Statistical combinations of searches for charginos and neutralinos using various decay channels are performed using 139  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. Searches targeting pure-wino chargino pair production, pure-wino chargino-neutralino production, or Higgsino production decaying via standard model W, Z, or h bosons are combined to extend the mass reach to the produced supersymmetric particles by 30-100 GeV. The depth of the sensitivity of the original searches is also improved by the combinations, lowering the 95% C.

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  • This study analyzed how cannabis use disorder (CUD) affects hospitalized patients undergoing urologic cancer surgeries, focusing on complications, length of stay (LOS), and inpatient costs (IC) from 2003 to 2014.
  • The findings revealed that the rate of CUD among patients increased significantly, with those affected being younger, more likely male, and from lower-income backgrounds, but CUD did not correlate with higher complication rates.
  • However, patients with CUD did experience longer hospital stays and higher costs, suggesting a need for further research on managing LOS and IC for these individuals.
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  • A study aimed to compare the effect of PSA screening on prostate cancer mortality between non-Hispanic Black (NHB) and non-Hispanic White (NHW) men, noting a lack of previous research on this topic.
  • The cohort included 6,378 men with prostate cancer, analyzed based on their PSA testing frequency prior to diagnosis, which showed that NHW men had a higher rate of annual testing compared to NHB men.
  • Results indicated that PSA screening significantly reduced the risk of prostate cancer-specific mortality for both racial groups, with the benefit of screening appearing to be independent of race.*
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  • * The measurements utilized both semileptonic and hadronic decays of top quarks, along with events focused on single top quark production in the electroweak t channel.
  • * The combined result for the top quark mass is 172.52 GeV, with a reduced total uncertainty of 0.33 GeV, showcasing an improvement of 31% over previous measurements.
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  • The study aimed to investigate how baseline PSA levels in men aged 40-59 predict the risk of lethal prostate cancer, focusing on modern cohorts rather than those from the pre-PSA screening era.
  • A total of 129,067 men were analyzed, with results showing that higher PSA levels (≥90th percentile) significantly increased the likelihood of developing lethal prostate cancer compared to those with lower levels, indicating a strong correlation.
  • The findings revealed that even in younger age groups (40-44), men with high PSA levels faced greater risks, emphasizing the importance of early PSA testing in assessing prostate cancer risk.
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A combination of searches for a new resonance decaying into a Higgs boson pair is presented, using up to 139  fb^{-1} of pp collision data at sqrt[s]=13  TeV recorded with the ATLAS detector at the LHC. The combination includes searches performed in three decay channels: bb[over ¯]bb[over ¯], bb[over ¯]τ^{+}τ^{-}, and bb[over ¯]γγ. No excess above the expected Standard Model background is observed and upper limits are set at the 95% confidence level on the production cross section of Higgs boson pairs originating from the decay of a narrow scalar resonance with mass in the range 251 GeV-5 TeV.

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Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is O(1  GeV). This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse impact parameter using 140  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV collected by the ATLAS experiment. For the first time since LEP, a range of mass splittings between the lightest charged and neutral Higgsinos from 0.

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Nanotechnology has revolutionized the fabrication of hybrid species with tailored functionalities. A milestone in this field is the deoxyribonucleic acid (DNA) conjugation of nanoparticles, introduced almost 30 years ago, which typically exploits the affinity between thiol groups and metallic surfaces. Over the last decades, developments in colloidal research have enabled the synthesis of an assortment of nonmetallic structures, such as high-index dielectric nanoparticles, with unique properties not previously accessible with traditional metallic nanoparticles.

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Angular correlations between heavy quarks provide a unique probe of the quark-gluon plasma created in ultrarelativistic heavy-ion collisions. Results are presented of a measurement of the azimuthal angle correlations between muons originating from semileptonic decays of heavy quarks produced in 5.02 TeV Pb+Pb and pp collisions at the LHC.

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  • This study examined prostate cancer-specific mortality (PCSM) among Black and White men by analyzing their other-cause mortality (OCM) risk to better understand healthcare access disparities.
  • Researchers used a large patient database from 2004 to 2009, matching Black and White men with similar OCM risks for comparison.
  • The findings revealed that when accounting for OCM risk, Black and White patients had similar rates of PCSM, suggesting that race did not significantly influence cancer survival rates at the population level.
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This Letter presents the first study of Higgs boson production in association with a vector boson (V=W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at sqrt[s]=13  TeV and corresponding to an integrated luminosity of 137  fb^{-1}. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb[over ¯].

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