Publications by authors named "Chiara Silva"
Article Synopsis
- * The study focused on identifying brain-specific DNA methylation profiles to track brain-derived cfDNA (bcfDNA) through comparisons of brain and non-brain tissues and validated these findings on autopsy samples.
- * The developed assay showed higher levels of bcfDNA in patients experiencing neurotoxicity after CAR-T therapy, indicating its potential for early detection of neuronal loss in neurodegenerative diseases.
Article Synopsis
- The study investigates the relationship between Demodex mite proliferation and rosacea flare-ups, focusing on both facial and scalp areas in patients with papulopustular rosacea.* -
- A standardized skin biopsy was performed to measure Demodex counts, revealing a significantly higher frequency of Demodex mites on the scalp and face in rosacea patients compared to controls.* -
- The primary species detected was Demodex folliculorum, suggesting that the scalp may serve as a reservoir for these mites, potentially complicating treatment effectiveness.*
A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices, which have been classified as "possibly carcinogenic"; however, their biological effects are unclear. As aberrant DNAm of genomic repetitive elements (REs) may promote genomic instability, here, we sought to determine whether exposure to RF-EMFs could affect DNAm of different classes of REs, such as long interspersed nuclear elements-1 (LINE-1), Alu short interspersed nuclear elements and ribosomal repeats.
View Article and Find Full Text PDFBackground and Objectives: To estimate the association between admission functional outcomes and exposure to physiotherapy interventions with mortality rate in intensive care unit (ICU) inpatients with cardiovascular diseases and new coronavirus disease (COVID-19). Materials and Methods: Retrospective cohort including 100 ICU inpatients (mean (standard deviation), age 75 (16) years) split into COVID-19+ or COVID-19−. The association of in-ICU death with admission functional outcomes and physiotherapy interventions was investigated using univariable and multivariable regression models.
View Article and Find Full Text PDF