Objectives: A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease. Evidence suggests that in selected patients, chronic opioids may be a valuable therapeutic option for RCM. The aim of the present study was to evaluate the effectiveness and safety of prophylaxis with low-dose methadone (LDM) in patients affected by RCM with continuous headache and MOH.
View Article and Find Full Text PDFAims: We aimed to improve the retention in treatment and therapeutic outcome of methadone maintenance treatment (MMT) patients by adjusting the oral methadone dose in order to reach a "target" plasma R-methadone level (80-250 ng/mL).
Methods: A multicenter randomized controlled trial was organized.
Results: The intention-to-treat statistical analysis showed that repeated dose adjustments performed in order to obtain therapeutic plasma R-methadone levels did not improve retention in treatment of heroin-dependent patients.
Aim: The aim of the present study is to explore the sexual functioning of an Eating Disorders (ED) sample composed by Anorexia Nervosa (AN), Bulimia Nervosa (BN) and Eating Disorders Not Otherwise Specified (EDNOS) patients.
Methods: 98 patients (AN: 23; BN: 14; EDNOS: 61) have been compared with 88 health subjects. All participants have filled in the following questionnaires: Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), Symptom Checklist-90 (SCL-90), Eating Disorders Examination (EDE-q), Binge Eating Scale (BES), Emotional Empathy Scale (EES).
Aim: In children, adolescents and subjects with intellectual disability (ID), psychotropic drugs are being used in large and increasing quantities. The aim of this article is to review efficacy and safety evidences of psychotropic drugs use in the above-mentioned patients.
Methods: A literature search on this argument was conducted on Medline electronic archives encompassing english-language and other languages publications.
Aim: Social Anxiety Disorder (SAD) represents one of the most frequent psychiatric disorders. The results of a systematic review of the literature published until January 2010 on the neurobiology of SAD are reported, giving prominence to functional neuroimaging (fNI) findings.
Methods: A literature search of neuroimaging and neurobiology studies of SAD was conducted on PubMed and Medline electronic archives and by canvassing English-language and other European languages publications.