Publications by authors named "Chiara Kessler"
Article Synopsis
- Transthyretin (ATTR) amyloidosis often goes undetected until significant cardiac damage occurs, but lumbar spinal stenosis (LSS) can serve as an early indicator for diagnosis.
- In a study of patients over 50 undergoing LSS surgery, amyloid was found in 78.7% of ligamentum flavum tissue samples, with 64.9% classified as ATTR.
- The presence of amyloid is linked to older age and increased thickness of the ligamentum flavum, suggesting that examining this tissue could help identify ATTR earlier and improve treatment decisions.
Transthyretin amyloidosis (ATTR amyloidosis) is a disease caused by deposition of transthyretin fibrils in organs and tissues, which causes their dysfunction. The clinical heterogeneity of ATTR amyloidosis and the variable presentation of symptoms at early disease stages, historically meant treatment delays. Diagnostic tools and therapy options of ATTR amyloidosis have markedly improved in recent years.
View Article and Find Full Text PDFSystemic amyloidosis is a heterogeneous group of diseases associated with protein misfolding into insoluble beta-sheet rich structures that deposit extracellularly in different organs, eventually compromising their function. There are more than 30 different proteins, known to be amyloidogenic with “light chain” (AL)-amyloidosis being the most common type, followed by transthyretin (ATTR)-, and amyloid protein A (AA)-amyloidosis. Systemic amyloidosis is a rare disease with an incidence of around 10 patients in 1 million inhabitants.
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