Publications by authors named "Chiara Goossens"
Article Synopsis
- Research indicates that stimulating pancreatic beta cell regeneration could help treat diabetes, utilizing zebrafish which can effectively regenerate these cells from ductal progenitors.
- A study identified the protein phosphatase calcineurin (CaN) as a significant factor influencing this regeneration process, where overexpressing CaN hindered the regenerative response while inhibiting it promoted beta cell regeneration.
- Interestingly, the increased proliferation of progenitor cells due to CaN inhibition was linked to their eventual exhaustion, suggesting that CaN plays a crucial role in balancing cell proliferation and differentiation to maintain an adequate pool of progenitors for beta cell regeneration.
ARP/ASCL transcription factors are key determinants of cell fate specification in a wide variety of tissues, coordinating the acquisition of generic cell fates and of specific subtype identities. How these factors, recognizing highly similar DNA motifs, display specific activities, is not yet fully understood. To address this issue, we overexpressed different ARP/ASCL factors in zebrafish ascl1a-/- mutant embryos to determine which ones are able to rescue the intestinal secretory lineage.
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