Publications by authors named "Chiara Furlan"
Article Synopsis
- - The text discusses a new type of nanogels made from a chitosan matrix, which are stabilized by a Mn-t-CDTA derivative and serve dual purposes as both a contrast medium and a cross-linking agent.
- - These nanogels offer significant advantages over traditional Gd(III) chelates, showing seven times higher relaxivity in clinical settings and maintaining high stability under physiological conditions.
- - They demonstrate effective accumulation in tumors with optimal contrast visible at 24 hours post-injection, making them potential candidates for advanced MRI imaging in medical applications.
Article Synopsis
- Cyclic peptoids are specialized molecules made of N-substituted glycines that have unique folding properties and strong metal-binding capabilities.
- This research explores how placing certain chiral units affects the stability of these peptoids when they form complexes with sodium in water.
- The findings are based on several advanced scientific methods, including nuclear magnetic resonance spectroscopy and X-ray diffraction, to analyze their structural properties and stability in the presence of gadolinium ions.
Gadolinium-based contrast agents (GBCAs) are massively employed in radiology to increase the diagnostic power of MRI. However, investigations aiming at detecting possible metabolic perturbations or adverse health effects due to gadolinium deposition are still lacking. In this work, aqueous organs extract and plasma samples were analyzed by GC-MS and H-NMR, respectively, to investigate the effects of multiple administrations of one linear (Omniscan) and one macrocyclic (ProHance) GBCA, on the main metabolic pathways in healthy mice.
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- This study aims to quantitatively assess how much Gadolinium (Gd) is retained in the central nervous system (CNS) and peripheral organs of mice with an immune-mediated model of Multiple Sclerosis (EAE) compared to control mice, as well as how the timing of Gd injection affects retention levels.* -
- EAE mice received three doses of Gd at different stages of disease progression, and following a set period, their organs were analyzed for Gd levels using advanced techniques such as Inductively Coupled Plasma-Mass Spectrometry and Transmission Electron Microscopy.* -
- Results showed higher Gd accumulation in the spinal cord of EAE mice shortly after injection, while levels decreased significantly over time; G
Purpose: Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups.
Methods: A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped).
Objectives: Being administered intravenously, the tissue that gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging mostly encounter is blood. Herein, it has been investigated how much Gd is internalized by cellular blood components upon the in vitro incubation of GBCAs in human blood or upon intravenous administration of GBCAs to healthy mice. We report results that show how the superb sensitivity of inductively coupled plasma-mass spectrometry (ICP-MS) allows the detection of very tiny amounts of GBCAs entering red blood cells (RBCs) and white blood cells (WBCs).
View Article and Find Full Text PDFObjectives: The aim of the study was to explore the role of the stability of metal complexes in the processes that lead to the metal retention in the brain and other tissues of mice administered with lanthanides-based contrast agents. This issue was tackled by the simultaneous injection of gadolinium (Gd)-diethylentriamminopentaacetate (DTPA) and lanthanum-DTPA, which have the same charge and structure but differ in their thermodynamic stability by 3 orders of magnitude.
Materials And Methods: A total of 20 healthy BALB/c mice were administered by a single intravenous injection with a dose consisting of 0.
Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma with a still undefined etiology. Several lines of evidence are consistent with the possible involvement of peculiar microenvironmental stimuli sustaining tumor cell growth and survival, as the activation of Toll-like receptors (TLR) 4 and 9. However, little is known about the contribution of other TLRs of pathogenic relevance in the development of MCL.
View Article and Find Full Text PDFHuman immunodeficiency virus p17 matrix protein is released by infected cells and may accumulate within lymphoid tissues where it may deregulate the biological activities of different cell populations by binding to CXCR1 and CXCR2 cellular receptors. S75X, a natural p17 variant, was recently shown to enhance the malignant properties of lymphoma cells. We investigated a reference p17 protein and the S75X variant for their ability to bind to Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes and trigger downstream effects of potential pathogenic relevance.
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