Publications by authors named "Chiara Domizio"
High-risk relapsed/refractory adult Philadelphia-negative (Ph-) B-cell acute lymphoblastic leukemia (B-ALL) is a great challenge due to limited possibilities to achieve and maintain a complete response. This also applies to cases with extramedullary (EM) involvement that have poor outcomes and no accepted standard therapeutic approaches. The incidence of EM localization in relapsed/refractory B-ALL is poorly investigated: data on patients treated with blinatumomab reported a 40% rate.
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- - Adult rhabdomyosarcoma (RMS) is a rare type of soft tissue sarcoma, making up less than 3% of cases, which leads to limited understanding of its clinical management and natural history.
- - Researchers studied the molecular biology of adult RMS, focusing on gene expression related to cell transition and drug resistance, utilizing patient-derived cultures and 3D models to assess drug response.
- - Key findings include the identification of potential biomarkers for RMS through RT-PCR, the highest drug sensitivity in anthracycline-based treatments, and significant genetic mutations linked to poor prognosis, contributing to a better understanding of this rare cancer.