Publications by authors named "Chiara De Stefani"
In the present study, polymeric micelles were developed to improve the intestinal permeability of an extract of L. leaf with a high content of total polyphenols (49% /), with 41% / corresponding to the oleuropein amount. A pre-formulation study was conducted to obtain a stable formulation with a high loading capacity for extract.
View Article and Find Full Text PDFOleanolic acid (OA) is the main triterpenic acid of olive leaves known for numerous pharmacological properties, including antioxidant activity. However, it is poorly soluble in water and consequently with low bioavailability, which limits its pharmacological application. Microemulsions (MEs) are dispersed systems consisting of two immiscible phases that promote rapid solubilization and absorption in the gastrointestinal tract.
View Article and Find Full Text PDFOleanolic acid (OA) is a pentacyclic triterpenoid widely found in the Oleaceae family, and it represents 3.5% of the dry weight of olive leaves. OA has many pharmacological activities, such as hepatoprotection, anti-inflammatory, anti-oxidant, anti-diabetic, anti-tumor, and anti-microbic activities.
View Article and Find Full Text PDFArticle Synopsis
- Thymoquinone (TQ) is the key component of L. essential oil and shows protective effects against oxidative stress in eye cells, as well as reducing inflammation in dry eye models in mice.
- To enhance TQ's therapeutic potential, two liposomal formulations were created, one of which is coated with hyaluronic acid (HA) to improve solubility and bioavailability, both with sizes under 200 nm and about 70% encapsulation efficiency.
- The HA-coated liposomes proved to be stable for two months, exhibited gradual TQ release, and showed reduced toxicity while enhancing cell absorption, particularly in human corneal and conjunctival epithelial cells.