Oxidative stress initiates hemodynamic change in CKD-induced heart disease.

Chronic kidney disease (CKD) predisposes to cardiac remodeling and coronary microvascular dysfunction. Studies in swine identified changes in microvascular structure and function, as well as changes in mitochondrial structure and oxidative stress. However, CKD was combined with metabolic derangement, thereby obscuring the contribution of CKD alone.

New neovagina-creating technique on the basis of a fasciocutaneous flap for Müllerian agenesis.

Objective: To present a new surgical technique on the basis of an internal thigh fasciocutaneous flap for generating a compliant and sensitive neovagina with preservation of the external genitalia.

Design: Video demonstration of the surgical steps.

Patient(s): An 18-year-old woman with Müllerian agenesis confirmed at ultrasound and magnetic resonance imaging.