Publications by authors named "Chiara Costantini"

Article Synopsis
  • The study investigates the effectiveness of transumbilical laparoscopic-assisted appendectomy (TULAA) in treating both uncomplicated (UA) and complicated appendicitis (CA) among children over a 5-year period.
  • Results show a low conversion rate of 3%, with longer operative time and hospital stays for CA cases compared to UA cases, but similar rates of surgical site infections.
  • The findings suggest that TULAA is safe, feasible, and cost-effective for managing both types of appendicitis, showing no significant disadvantage compared to conventional laparoscopic surgery.
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Article Synopsis
  • Congenital vaginal atresia is a rare condition affecting the female reproductive system, which poses challenges for surgical procedures like vaginoplasty due to the risk of vaginal narrowing afterwards.
  • A case study involves an 11-year-old girl with Down syndrome who presented with pelvic pain, revealing an imperforate hymen and absence of the lower vagina, leading to a diagnosis of congenital vaginal agenesis.
  • To assist post-surgery, an epistaxis catheter was utilized as a makeshift vaginal dilator, providing a viable alternative for maintaining vaginal openness in patients who struggle with traditional dilators.
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The calcification of ligamentum arteriosum occurs after the normal closure of the ductus arteriosus. Foreign body ingestion is a common event in the pediatric age, and it is frequently addressed in the Emergency Room. We report a case of foreign body in a patient with unknown calcification of the ligamentum arteriosum.

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Background: The novel coronavirus brought Intensive Care Units (ICUs) back to their past when they were closed to family members. The difficulties of family caregivers encountered after the ICU discharge might have been increased during the coronavirus disease 2019 (COVID-19) pandemic. However, no traces of their experience have been documented to date.

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Aim: Aim of the study was to validate the Italian version of the Neuropsychiatric Inventory-Nursing Home (NPI-NH). The evaluation of neuropsychiatric symptoms in elderly patients with cognitive impairment and/or a chronic psychiatric disorder, is an essential need in nursing home.

Methods: The Italian version of the NPI-NH was administered in 53 patients in a nursing home in Northern-Italy.

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Purpose: The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer.

Patients And Methods: Patients with advanced gastric cancer that progressed after one or two lines of systemic chemotherapy were randomly assigned to everolimus 10 mg/d (assignment schedule: 2:1) or matching placebo, both given with BSC.

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Background: Many studies indicate that migrants in western countries have limited access to and low utilization of community mental health centres (CMHCs) despite the high prevalence of mental disorders.

Aims: We aimed to compare migrant pathways to care across four CMHCs located in different Italian provinces and to identify pathway to care predictors.

Methods: Migrants attending the four CMHCs between 1 July 1999 and 31 December 2007 were included in the study.

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Paediatric emergency management is a very stressful clinical event especially when it occurs in a non paediatric hospital. Low self confidence, non familiarity with drug dosages and proper equipment selection are the main cause of professional insecurity. In this paper, after a short review dealing with main differences between child and adult patient, we consider the advantages offered by Broselow method approach to paediatric emergences.

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Aim: Aim of this study was to investigate metabolic effects of second generation antipsychotics (SGA) in drug naïve patients.

Methods: we included patients with psychotic disorders who were treated for the first time with a SGA. We evaluate anthropometric and metabolic data at baseline, after three months and after a year.

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Background: Polypharmacy is regarded as an important risk factor for fallingand several studies and meta-analyses have shown an increased fall risk in users of diuretics, type 1a antiarrhythmics, digoxin and psychotropic agents. In particular, recent evidence has shown that fall risk is associated with the use of polypharmacy regimens that include at least one established fall risk-increasing drug, rather than with polypharmacy per se. We studied the role of polypharmacy and the role of well-known fall risk-increasing drugs on the incidence of injurious falls.

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Many cases of coeliac disease, a gastrointestinal autoimmune disorder caused by sensitivity to gluten, can remain in a subclinical stage or undiagnosed. In a significant proportion of cases (10-15%) gluten intolerance can be associated with central or peripheral nervous system and psychiatric disorders.A 38-year-old man was admitted as to our department an inpatient for worsening anxiety symptoms and behavioural alterations.

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Background: In spite of the high prevalence of psychiatric disorders among elderly residents in nursing homes, only a small number of patients in need of specialist care are referred to a psychiatric consultant. The aim of this research was to evaluate the consultation activity and the appropriateness of referral to psychiatric assessment.

Methods: Data were collected and analysed on consultation carried out over a two-year period in a RSA (Residenza Socio-Assistenziale) in Northern-Italy.

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We have analysed a series of 96 patients with multiple myeloma (MM) to the purpose to verify the prognostic meaning of the beta2-microglobulin (B2M) and the validity of the staging systems proposed by Bataille and Jacobson who use the B2M respectively associated to the serum C-reactive protein (CRP) and to the serum albumin. In our series of patients the serum level of B2M at the diagnosis was directly correlated with the myelomatous cellular mass. We have found besides an inverse correlation between B2M and survival.

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