The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation.

Aims: The cardio-protective and immuno-regulatory properties of RTP-026, a synthetic peptide that spans the Annexin-A1 (AnxA1) N-terminal region, were tested in rat acute myocardial infarction.

Methods And Results: In vitro, selective activation of formyl-peptide receptor type 2 (FPR2) by RTP-026 occurred with apparent EC in the 10-30 nM range. With human primary cells, RTP-026 counteracted extension of neutrophil life-span and augmented phagocytosis of fluorescent E.

Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain.

Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model recapitulates both association and dissociation between pain and joint inflammation in RA. Furthermore, this model features monocyte/macrophage infiltration in joints and lumbar dorsal root ganglia (DRG), where these immune cells are close to nociceptive neurons. We focussed on CXCR-monocyte/macrophage trafficking and show that at peak paw swelling associated with nociception, CXCR deletion altered neither swelling nor macrophage infiltration/phenotype in paws.