Publications by authors named "Chiara Barile"
Article Synopsis
- * Research found that the EphB6 receptor is significantly overexpressed in T-ALL, particularly in a small cell population that exhibits high LIC activity and is associated with poor clinical outcomes.
- * Targeting EphB6+ cells may offer a new therapeutic strategy for treating T-ALL, as they play a crucial role in the disease’s progression and resistance to standard treatments.
Background: Glioblastoma (GBM) is the most malignant among gliomas with an inevitable lethal outcome. The elucidation of the physiology and regulation of this tumor is mandatory to unravel novel target and effective therapeutics. Emerging concepts show that the minor subset of glioblastoma stem cells (GSCs) accounts for tumorigenicity, representing the true target for innovative therapies in GBM.
View Article and Find Full Text PDFBackground: Glioblastoma multiforme (GBM) is an incurable tumor, with a median survival rate of only 14-15 months. Along with heterogeneity and unregulated growth, a central matter in dealing with GBMs is cell invasiveness. Thus, improving prognosis requires finding new agents to inhibit key multiple pathways, even simultaneously.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) harboring BRAF mutation exhibits low response to conventional therapy and poorest prognosis. Due to the emerging correlation between gut microbiota and CRC carcinogenesis, we investigated in serrated BRAF cases the existence of a peculiar fecal microbial fingerprint and specific bacterial markers, which might represent a tool for the development of more effective clinical strategies.
Methods: By injecting human CRC stem-like cells isolated from BRAF patients in immunocompromised mice, we described a new xenogeneic model of this subtype of CRC.