Publications by authors named "Chiara Ambuehl"
Six extracts from the roots and the aerial parts of Waltheria indica L. (Malvaceae) were screened for their in vitro antitrypanosomal activity towards Trypanosoma brucei brucei STIB 427 strain, T. brucei rhodesiense STIB 900 and Trypanosoma cruzi Tulahuen C4.
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- A chemical study of Waltheria indica's dichloromethane root extract isolated 10 quinoline alkaloids, including 8-deoxoantidesmone and waltheriones E-L, with new compounds characterized using various spectroscopic techniques.
- The chemical structures were confirmed through advanced spectroscopy methods, and absolute configurations were validated through comparison with theoretical ECD spectra.
- Some isolated compounds demonstrated strong antitrypanosomal activity against Trypanosoma cruzi, particularly compounds 4, 5, and 8, which showed low IC50 values, indicating effectiveness at minimal concentrations.