Publications by authors named "Chiappetta Marco"
Objectives: To investigate whether 18F-fluorodeoxyglucose positron emission tomography-computed tomography ([F]F-FDG PET/CT) metabolic parameters were associated with histology and to assess their prognostic role in patients with thymic lesions.
Patients And Methods: In total, 116 patients (49/67 M/F; mean age 59.5 years) who underwent preoperative [F]F-FDG PET/CT and thymectomy from 2012 to 2022 were retrospectively analyzed.
Lung cancer is still a leading cause of cancer-related deaths worldwide. Vital to ameliorating patient survival rates are early detection, precise evaluation, and personalized treatments. Recent years have witnessed a profound transformation in the field, marked by intricate diagnostic processes and intricate therapeutic protocols that integrate diverse omics domains, heralding a paradigm shift towards personalized and preventive healthcare.
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- Pulmonary metastasectomy (PM) is effective for treating oligometastatic cancer and aims to preserve lung function and quality of life through a lung-sparing surgical approach.
- The manuscript discusses the authors' experience with a unique technique called uniportal laser-assisted VATS (U-LA-VATS) for PM, emphasizing the use of specialized laser equipment and tools during the procedure.
- Out of 98 patients who had PM between March 2021 and November 2023, 24 were treated with the laser-assisted method, with the study presenting their results and comparing them to existing literature on the topic.
Article Synopsis
- The study analyzes the genetic profiles of recurrent thymomas, using samples from 23 patients out of a cohort of 426 thymomas for comparison with primary tumors and a control group of non-recurrent cases.
- Comprehensive genetic profiling (CGP) was conducted using the NGS Tru-Sight Oncology assay, revealing no significant differences in genetic alterations between initial tumors and recurrent ones, nor between recurrent and non-recurrent thymomas.
- However, it was found that cell cycle control gene alterations are linked with early recurrence, and over 50% of patients may qualify for potential targeted therapies through a precision medicine approach.
Article Synopsis
- A study analyzed the neurological outcomes of patients over 65 with myasthenia gravis (MG) who underwent thymectomy for thymoma between 2000 and 2022, focusing on a cohort of 66 patients affected by both conditions.
- Most patients showed significant improvement post-surgery, with 88% reporting better neurological status, although the study found no clear link between outcomes and various factors such as age of MG onset or type of surgery.
- The results suggest thymectomy is effective for improving symptoms in older MG patients, and further clinical trials are recommended to investigate the benefits of minimally invasive surgery in this group.
Artificial Intelligence (AI) has revolutionized the management of non-small-cell lung cancer (NSCLC) by enhancing different aspects, including staging, prognosis assessment, treatment prediction, response evaluation, recurrence/prognosis prediction, and personalized prognostic assessment. AI algorithms may accurately classify NSCLC stages using machine learning techniques and deep imaging data analysis. This could potentially improve precision and efficiency in staging, facilitating personalized treatment decisions.
View Article and Find Full Text PDFBackground: Completion lobectomy (CL) following a prior resection in the same lobe may be complicated by severe pleural or hilar adhesions. The role of uniportal video-assisted thoracoscopic surgery (U-VATS) has never been evaluated in this setting.
Methods: Data were collected from two Italian centers.
Article Synopsis
- The study looked at patients with a type of cancer called thymoma who had it come back after treatment and underwent surgery.
- They reviewed data from 40 patients and found that most had relapses in the chest or lungs, and some received extra treatments after surgery.
- The results showed that patients with less aggressive cancer types had a higher chance of surviving longer, especially when they got additional treatment.
Article Synopsis
- The study investigates the impact of the number of involved structures (NIS) on the prognosis of patients with thymic epithelial tumors (TETs) who underwent surgery, using data from the European Society of Thoracic Surgeons (ESTS) thymic database.
- Out of 303 patients analyzed, those with more than two involved structures had significantly worse cancer-specific survival (CSS) compared to those with two or fewer, with 5-year CSS rates of 9.5% versus 93.2%, respectively.
- Factors such as neoadjuvant therapy, complete resection, and thymoma histology were associated with better prognosis, highlighting the importance of NIS in determining patient outcomes.
The BAP1 tumor suppressor gene encodes a deubiquitinase enzyme involved in several cellular activities, including DNA repair and apoptosis. Germline pathogenic variants in BAP1 have been associated with heritable conditions including BAP1 tumor predisposition syndrome 1 (BAP1-TPDS1) and a neurodevelopmental disorder known as Kury-Isidor syndrome (KURIS). Both these conditions are caused by monoallelic, dominant alterations of BAP1 but have never been reported in the same subject or family, suggesting a mutually exclusive genotype-phenotype correlation.
View Article and Find Full Text PDFObjectives: Aim of this study is to identify the factors that may influence the lymphadenectomy during VATS anatomical lung resection with particular interest on operator experience.
Materials And Methods: Clinical and pathological data from the prospective VATS Italian nationwide registry were reviewed and analysed. Patients with incomplete data regarding tumor and surgical characteristics, GGO, or with distant metastases were excluded.
The genetic susceptibility in the development of malignant pleural mesothelioma: somatic and germline variants, clinicopathological features and implication in practical medical/surgical care: a narrative review.
J Thorac Dis
January 2024
Article Synopsis
- - Malignant pleural mesothelioma (MPM) is a highly aggressive cancer linked primarily to asbestos exposure, but recent trends show a growing number of cases without clear asbestos links, suggesting genetic factors may also play a significant role in susceptibility.
- - About 20% of MPM cases could be influenced by genetic predisposition, particularly involving the BAP1 gene, where those carrying specific variants tend to experience less aggressive forms of the disease and have different treatment needs.
- - The review summarizes research on both genetic (germline) and non-genetic (asbestos-related) causes of MPM, highlighting the importance of genetic testing and surveillance for at-risk individuals.
Background: Despite recent improvement in preoperative staging, nodal and mediastinal upstaging occur in about 5% to 15% of cN0 patients. Different clinical and tumor characteristics are associated with upstaging, whereas the role of the surgeon's experience is not well evaluated. This study aimed to investigate if operator experience might influence nodal upstaging during video-assisted thoracic surgery anatomical lung resection.
View Article and Find Full Text PDFAre the Efficacy and Safety of Chest Tubes in Uniportal Video-Assisted Thoracic Surgery Related to the Level of Intercostal Space Insertion or to the Drain Type? A Prospective Multicenter Study.
J Clin Med
January 2024
Objectives: The aim of this study is to evaluate if the efficacy and safety of chest tube placement are influenced by the level of intercostal space insertion (uniportal VATS vs. biportal VATS) or by the type of drain employed (standard vs. smart coaxial drain).
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- Thymic tumours are currently classified mainly by local invasiveness rather than size, prompting a study on how tumour dimensions affect survival rates in surgical patients.
- A retrospective analysis of 332 patients with thymic epithelial tumours found high five- and ten-year overall survival rates, with additional correlations to factors like male sex and older age influencing tumour size.
- Although tumour dimension alone was not a strong predictor of disease-free or overall survival, multivariate analysis suggested it could improve the TNM staging system for these tumours.