Morphine-potentiated platelet aggregation in in vitro and platelet plug formation in in vivo experiments.

The detailed mechanisms underlying morphine-signaling pathways in platelets remain obscure. Therefore, we systematically examined the influence of morphine on washed human platelets. In this study, washed human platelet suspensions were used for in vitro studies.

Morphine-potentiated agonist-induced platelet aggregation through alpha2-adrenoceptors in human platelets.

Morphine dose-dependently (0.6, 1, and 5 microM) potentiated platelet aggregation and ATP release stimulated by agonists (i.e.