Carboxyl-CNTs Act as "Defensive Shield" to Boost Proton Insertion for Stable and Fast-Charging Aqueous Zn-Mn Batteries.

Proton insertion mechanism with fast reaction kinetics is attracting more and more attention for high-rate and durable aqueous Zn─MnO batteries. However, hydrated Zn insertion reaction accompanied with Jahn-Teller effect and Mn disproportionation generally leads to sluggish rate capability and irreversible structure transformation. Here, carboxyl-carbon nanotubes supported α-MnO nanoarrays (C─MnO) cathode is successfully fabricated by a convent grinding process for high-performance Zn batteries.

Traditional Chinese medicine in synergy with conventional therapy improves renal outcomes and provides survival benefit in patients with systemic lupus erythematosus: a cohort study from the largest health care system in Taiwan.

Background: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that significantly impacts renal function. Despite conventional treatments, morbidity and mortality remain high, necessitating the exploration of safer and more effective therapies, including the potential benefits of Traditional Chinese Medicine (TCM) for improving kidney health and survival rates.

Methods: Patients with newly diagnosed with SLE with catastrophic illness certificate were retrospectively enrolled from CGRD between 2005 and 2020.

Investigating visual perception abilities in flight cadets: the crucial role of the lingual gyrus and precuneus.

Introduction: In aviation, exceptional visual perception is crucial for pilots to monitor flight instruments and respond swiftly to deviations, as well as make rapid judgments regarding environmental changes, ensuring aviation safety. However, existing research on pilots' visual perception has predominantly focused on behavioral observations, with limited exploration of the neurophysiological mechanisms involved.

Methods: This study aimed to investigate the brain activity associated with the visual perception capabilities of flight cadets.

Deep learning-based multi-task prediction of response to neoadjuvant chemotherapy using multiscale whole slide images in breast cancer: A multicenter study.

Objective: Early predicting response before neoadjuvant chemotherapy (NAC) is crucial for personalized treatment plans for locally advanced breast cancer patients. We aim to develop a multi-task model using multiscale whole slide images (WSIs) features to predict the response to breast cancer NAC more finely.

Methods: This work collected 1,670 whole slide images for training and validation sets, internal testing sets, external testing sets, and prospective testing sets of the weakly-supervised deep learning-based multi-task model (DLMM) in predicting treatment response and pCR to NAC.

PADI4 facilitates stem-like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma.

Background: Oesophageal squamous cell carcinoma (OSCC) is a highly lethal cancer characterized by its aggressive nature and chemotherapy resistance. Peptidylarginine deiminase 4 (PADI4) regulates protein citrullination and is associated with various cancer developments. The role of PADI4 in OSCC progression and chemoresistance remains unexplored.

Type II ZnO-MoS Heterostructure-Based Self-Powered UV-MIR Ultra-Broadband p-n Photodetectors.

This study presents the fabrication and characterization of ZnO-MoS heterostructure-based ultra-broadband photodetectors capable of operating across the ultraviolet (UV) to mid-infrared (MIR) spectral range (365 nm-10 μm). The p-n heterojunction was synthesized via RF magnetron sputtering and spin coating, followed by annealing. Structural and optical analyses confirmed their enhanced light absorption, efficient charge separation, and strong built-in electric field.

Optimization of Encapsulation Core-Shell Structure to Preserve Polyphenols in Soy Protein-Polysaccharide Co-Dried Complexes.

Polyphenols from extra virgin olive oil (EVOO) are bioactive compounds with significant antioxidant properties, but their instability necessitates effective encapsulation for enhanced stability and controlled release. This study prepared water-in-oil-in-water (W1/O/W2) emulsions to encapsulate EVOO using a two-step emulsification technique with varying concentrations of soy protein isolate (SPI) (0-10% /), maltodextrin (MD) (0-20% /), and propylene glycol alginate (PGA) (0-0.5% /).

Hypothalamus Transcriptome Reveals Key lncRNAs and mRNAs Associated with Fecundity in Goats.

The hypothalamus (hyp) serves as the regulatory hub of the neuroendocrine system, synthesizing and secreting reproductive hormones that modulate estrus, follicular maturation, and embryonic development in goats. This study employed RNA-seq analysis to examine gene expression in the hypothalamic tissue of Yunshang black goats during the luteal phase in goats with high fecundity (LP_HY), during the luteal phase in goats with low fecundity (LP_LY), during the follicular phase in goats with high fecundity (FP_HY), and during the follicular phase in goats with low fecundity (FP_LY). Differential long non-coding RNAs (DE lncRNAs) and differential mRNAs (DE mRNAs) were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses and the construction of co-expression networks associated with reproduction.

Advances in Novel Diagnostic Techniques for Alveolar Echinococcosis.

Alveolar echinococcosis (AE), caused by the larval stage of the tapeworm , is a serious parasitic disease that presents significant health risks and challenges for both patients and healthcare systems. Accurate and timely diagnosis is essential for effective management and improved patient outcomes. This review summarizes the latest diagnostic methods for AE, focusing on serological tests and imaging techniques such as ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT).

Radiotherapy Increases Carotid Intima-Media Thickness in Patients with Nasopharyngeal Carcinoma Compared to a Healthy Control Group: A 6-Year Follow-Up Study.

Vascular abnormalities are the primary histological changes in individuals undergoing radiotherapy for nasopharyngeal carcinoma (NPC). We sought to validate the hypothesis that the duration post-radiotherapy is linked to the progression of carotid intima-media thickness (IMT) and further explored its connection with mortality. Twenty-nine NPC patients who underwent radiotherapy and seventeen healthy controls were examined by carotid ultrasound for measurement of IMT and carotid plaque score at the common carotid artery (CCA), carotid bifurcation, and internal carotid artery, with follow-ups more than 6 years.

Model Predicting Survival in Intermediate-Stage HCC Patients Reclassified for TACE Based on the 2022 BCLC Criteria.

: The Barcelona Clinic Liver Cancer (BCLC) staging system for hepatocellular carcinoma (HCC) was updated in 2022 to refine patient stratification, particularly in patients with intermediate-stage (BCLC B) HCC. Although transarterial chemoembolization (TACE) remains a key treatment for these patients, there is no prognostic model for survival outcomes based on the pretreatment factors of patients who meet the updated 2022 BCLC indications for TACE. The aim of this study was to develop a pretreatment risk model predicting overall survival (OS) in patients with intermediate-stage HCC and reclassified as candidates for TACE according to the updated 2022 BCLC criteria.

A Novel Digital PCR Assay for Accurate Detection and Differentiation of Focal and Non-Focal Subtypes of Mesenchymal-Epithelial Transition () Gene Amplification in Lung Cancer.

Background/objectives: Mesenchymal-epithelial transition () gene amplification is a critical biomarker in non-small cell lung cancer (NSCLC), significantly influencing treatment decisions and prognostic evaluations. However, current detection methods such as fluorescence in situ hybridization (FISH) and next-generation sequencing (NGS) have limitations in speed, cost, and specificity, particularly when distinguishing between focal amplification and polysomy.

Methods: This study introduces a novel digital PCR (dPCR) assay designed not only to detect amplification but also to differentiate between its focal and non-focal subtypes.

Status and frontiers of Fabre disease.

Fabry disease is characterized by an X sex chromosome gene mutation caused by α-galactosidase A deficiency, resulting in the accumulation of globotriaosylceramide and globotriaosylsphingosine in various organs, which induces end-organ lesions. In Fabry disease, enzymes with lost or decreased activity in the body are replaced by exogenous supplementation of normal-function α-galactosidase A. Currently, agalsidase α and agalsidase β are widely used for ERT therapy.

Epidemiological and etiological investigation of a rare family cluster caused by severe fever with thrombocytopenia syndrome in Anhui Province in 2023.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease discovered in the 21st century. Human-to-human transmission of the disease has been documented, but the mechanisms of transmission require further investigation.

Methods: Epidemiological investigations and genetic analyses of the patients were conducted, and a retrospective cohort study was performed to analyze potential risk factors for person-to-person transmission.

Successful treatment of choroidal hemangiomas in Sturge-Weber syndrome using external beam radiotherapy.

Sturge-Weber syndrome (SWS) is a rare congenital disorder with diverse manifestations, including diffuse choroidal hemangiomas causing visual impairment. This case report describes a 14-year-old girl with retinal detachment due to diffuse choroidal hemangioma, treated effectively using external beam radiation therapy (EBRT). The treatment achieved a significant 55% reduction in choroidal thickness after the first phase and near-complete remission after supplementary therapy.

Differentiation of anterior chamber pigment and inflammatory cells using swept-source optical coherence tomography: a cross-sectional study.

Background/objectives: We aimed to investigate the potential of anterior segment OCT (AS-OCT) in differentiating anterior chamber (AC) pigment and inflammatory cells.

Subject/methods: Cross-sectional study of adults with uveitis. The exclusion criterion was corneal opacity sufficient to obscure slit lamp examination of the anterior chamber.

Exploration of the relationship between the height of the popliteal artery injury plane and the risk of amputation.

Purpose: The aim of the present study was to explore the impact of different planes of popliteal artery injury (PAI) on the risk of amputation in affected limbs.

Methods: A retrospective analysis was conducted on ninety-four patients who underwent PAI; these patients were divided into an amputation group (n = 26) and a nonamputation group (n = 68) on the basis of whether limb preservation was successful. The data were reconstructed from computed tomography angiography (CTA) of the patients' lower limbs and measured via AW Volume Share 5 software.

Soft tissue manipulation enhances recovery of muscle mass in a disuse model of sarcopenia.

Context: Sarcopenia is a disease characterized by low muscle mass and function that places individuals at greater risk of disability, loss of independence, and death. Current therapies include addressing underlying performance issues, resistance training, and/or nutritional strategies. However, these approaches have significant limitations, and chronic inflammation associated with sarcopenia may blunt the anabolic response to exercise and nutrition.

Ergonomics in the Operating Room: Recommendations for Orthopaedic Surgeons.

Orthopaedic surgeons face notable occupational hazards, including suboptimal ergonomics in the operating room (OR). This results in high rates of musculoskeletal injuries that affect at least four in 10 orthopaedic surgeons. Sex disparities exacerbate these issues, with female surgeons reporting markedly higher rates of occupational injuries and discomfort with surgical instrument use compared with male surgeons.

Clinical characterization of diseases associated with anti-N-methyl-D-aspartate receptor encephalitis combined with anti-myelin oligodendrocyte glycoprotein antibodies in adults.

Objective: The aim of this study was to analyze the clinical characteristics of adult patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis combined with anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.

Methods: This was a non-randomized controlled study. Clinical data were collected from 17 patients with anti-NMDAR encephalitis combined with anti-MOG antibodies admitted to Xuanwu Hospital, Capital Medical University, from January 2020 to August 2024.

In-device Battery Failure Analysis.

Lithium-ion batteries are indispensable power sources for a wide range of modern electronic devices. However, battery lifespan remains a critical limitation, directly affecting the sustainability and user experience. Conventional battery failure analysis in controlled lab settings may not capture the complex interactions and environmental factors encountered in real-world, in-device operating conditions.

Stressful Life Events and Neuroticism among Chinese Women with Recurrent Major Depressive Disorder.

Background: Depression is associated with a high incidence of stressful life events (SLEs) and neuroticism. However, the impact of SLEs and neuroticism on the recurrence of major depressive disorder (MDD) remains unclear. Therefore, we aimed to identify the potential causal relationship between SLEs, neuroticism, and depression recurrence.

Transcriptome analyses reveal key genes related to pod dehiscence of adzuki bean ().

Unlabelled: To investigate the mechanism of pod dehiscence in adzuki bean, RNA sequencing was utilized to analyze transcriptomes in the ventral and dorsal sutures of pods from two dehiscence-resistant accessions and two dehiscence-susceptible accessions. A total of 943 differentially expressed genes (DEGs) were identified. Through the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic enrichment pathways, 34 genes related to pod dehiscence were identified.

Diagnostic value of magnetic resonance imaging for malignant ovarian tumors mis-subclassified by the ultrasound-based ADNEX model.

Objective: Accurately predicting metastatic cancer to the adnexa, stage I and advanced ovarian cancer before surgery is crucial. The ADNEX model, based on ultrasound, is currently the only prediction model that can differentiate between these types. This study aims to analyze MRI features and diagnostic value in malignant ovarian tumors mis-subclassified by the ADNEX model, considering their diverse histopathologic types.

Nomograms of risk prediction and prognosis for the T1-T2 stage gastric cancer with lymph node metastasis: a population-based study.

Background And Aims: Lymph node metastasis plays a crucial role in determining the appropriate treatment approach for patients with gastric cancer (GC), particularly those in the T1-T2 stage. Currently available diagnostic strategies for GC with lymph nodes have limited accuracy. The present research aimed to create and validate diagnostic and prognostic nomograms specifically tailored for the T1-T2 stage GC patients with LNM.