Publications by authors named "Chiao Ling Jennifer Shen"
Structure of the conserved Francisella virulence protein FvfA.
Acta Crystallogr D Struct Biol
October 2017
Article Synopsis
- Francisella tularensis is a dangerous pathogen that thrives in immune cells, specifically macrophages and epithelial cells.
- Two proteins, FTT_0924 and FTL_1286, help the bacteria survive harmful conditions and evade destruction within these immune cells.
- The study focuses on the crystal structure of FvfA, a related protein, revealing its similarities to E. coli's RscF and discussing how these structural features may influence the bacteria's ability to cause disease.
Francisella novicida is a surrogate pathogen commonly used to study infections by the potential bioterrorism agent, Francisella tularensis. One of the primary sites of Francisella infections is the liver where >90% of infected cells are hepatocytes. It is known that once Francisella enter cells it occupies a membrane-bound compartment, the Francisella-containing vacuole (FCV), from which it rapidly escapes to replicate in the cytosol.
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