Impact of natural views on mental health during COVID-19 quarantine: A natural experiment.

The COVID-19 pandemic has changed the daily lives of people, and countries worldwide have implemented public health measures that restricted social contact and interactions. Individuals in isolation displayed increased mental health issues, for whom windows are a crucial means of connecting with the outside world. However, few studies have discussed the effect of having a window view on the mental health of individuals in quarantine.

Graphene-Multiwalled Carbon Nanotubes Modified Glassy Carbon Electrodes for Simultaneous Detection of Ascorbic Acid, Dopamine, and Uric Acid.

This study compares the sensing performance of glassy carbon electrodes (GCE) modified with graphene (GR), multiwalled carbon nanotubes (MWCNTs), and graphene-multiwalled carbon nanotube (GR-MWCNT) composites for the simultaneous detection of ascorbic acid (AA), dopamine (DA), and uric acid (UA). Among these electrodes, GR-MWCNT/GCE exhibited the highest sensitivity and the lowest detection limit. Using differential pulse voltammetry (DPV), AA, DA, and UA can be simultaneously detected at low potentials of -0.

Early Potentially Irreversible Cardiac Damage in Fabry Disease Precedes Gb3 Inclusion Body Formation.

Background: Fabry disease (FD) is a lysosomal storage disorder impacting multiple organs, including the heart. We investigated whether early-stage globotriaosylceramide (Gb3) accumulation, occurring before the formation of inclusion bodies, could cause significant stress and potentially irreversible damages of the cardiac tissue in FD patients.

Methods: Immunofluorescent (IF) staining and Western blotting were performed on fibroblasts from FD IVS4 patients and myocardial biopsies from G3Stg/GLAko mice as well as three IVS4 patients (aged 44, 37, and 41 years).

IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment.

Background: Glioblastoma multiforme (GBM) is an aggressive brain tumor with chemoresistant, immunosuppressive, and invasive properties. Despite standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, tumors inevitably recur in the peritumoral region. Targeting GBM-mediated immunosuppressive and invasive properties is a promising strategy to improve clinical outcomes.

Bacterial estrogenesis without oxygen: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere.

Androgen and estrogen, key sex hormones, were long thought to be exclusively produced by vertebrates. The O-dependent aromatase that converts androgen to estrogen (estrogenesis) has never been identified in any prokaryotes. Here, we report the finding of anaerobic estrogenesis in a Peptococcaceae bacterium ( sp.

Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single-Cell Secretory and Intracellular Dynamics.

Current imaging technologies are limited in their capability to simultaneously capture intracellular and extracellular dynamics in a spatially and temporally resolved manner. This study presents a multimodal imaging system that integrates nanoplasmonic sensing with multichannel fluorescence imaging to concomitantly analyze intracellular and extracellular processes in space and time at the single-cell level. Utilizing a highly sensitive gold nanohole array biosensor, the system provides label-free and real-time monitoring of extracellular secretion, while implementing nanoplasmonic-compatible multichannel fluorescence microscopy enables to visualize the interconnected intracellular activities.

Effects of Fingered Citron (Citrus medica var. sarcodactylis) Essential Oil on Improvement in Diet-Induced Hyperlipidemia Syrian Hamsters.

Preventing hyperlipidemia and the risk of cardiovascular disease are attractive to public health. Essential oils are extremely promising nutrients for use in the treatment of hyperlipidemia, whose effectiveness is closely related to its volatile composition. We extracted fingered citron essential oil (FCEO) with steam distillation, analyzed the chemical composition, and evaluated its effects on hyperlipidemia.

Metabolic alterations in HSCs during aging and leukemogenesis.

Aging is a multifaceted process associated with a functional decline in cellular function over time, affecting all lifeforms. During the aging process, metabolism, a fundamental hallmark of life (1), is profoundly altered. In the context of hematopoiesis, the proper function of hematopoietic stem cells - at the apex of the blood system - is tightly linked to their energy metabolism, which in turn shapes hematopoietic output.

Development and validation of the Chinese Rural Middle-aged and Elderly Health Literacy Scale.

Introduction: A notable deficiency lies in the absence of tailored instruments for comprehensively evaluating the health literacy of middle-aged and elderly residents in rural areas of China. Given the context of China's ageing demographic and the increasing urban-rural disparities, it becomes imperative to formulate a dedicated assessment tool for appraising the health literacy of rural middle-aged and elderly populations.

Methods: A systematic and rigorously structured development approach was used.

Surfactin inhibits enterococcal biofilm formation via interference with pilus and exopolysaccharide biosynthesis.

Enterococcus faecalis is a significant pathogen in healthcare settings and is frequently resistant to multiple antibiotics. This resistance is compounded by its ability to form biofilms, dense bacterial communities that are challenging to eliminate via standard antibiotic therapies. As such, targeting biofilm formation is considered a viable strategy for addressing these infections.

Optimized Graphene-Oxide-Based Interconnecting Layer in All-Perovskite Tandem Solar Cells.

All-perovskite tandem solar cells represent a significant advancement in next-generation photovoltaics toward higher power conversion efficiencies than single junction cells. A critical component of a monolithic tandem solar cell is the interconnecting layer, which facilitates the integration of the wide bandgap and low bandgap subcells. Conventional designs in all-perovskite tandem cells are based on an ultrathin metal recombination layer, typically Au, alongside a poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) hole transporting layer, which introduce optical and recombination losses, and instabilities.

Efficient perovskite LEDs with tailored atomic layer number emission at fixed wavelengths.

Colloidal quantum dots (QDs) have illuminated computer monitors and television screens due to their fascinating color-tunable properties depending on the size. Here, the electroluminescence (EL) wavelength of perovskite LEDs was tuned via the atomic layer number (ALN) of nanoplates (NPs) instead of the "size" in conventional QDs. We demonstrated efficient LEDs with controllably tailored emission from = 3, 4, 5, and ≥7 ALN perovskite NPs with specific and discrete major peaks at 607, 638, 669, and 728 nanometers.

Screening for hearing impairment in newborns using targeted genomic sequencing: a large pilot cohort study.

Objective: Current state-run newborn hearing screening (NBHS) programs have limitations in identifying children with mild or late-onset sensorineural hearing impairment (SNHI). As more than 50% of pediatric SNHI cases are attributed to genetic causes, these limitations may be addressed by the increasing accessibility of high-throughput, low-cost genomic sequencing. This study aims to investigate the feasibility of integrating a next-generation sequencing (NGS)-based genomic screening protocol into conventional NBHS and to examine its potential benefits and challenges.

Defining the Role of Adjuvant Radiotherapy for Biliary Tract Cancers: A Site-Specific Propensity-Matched Analysis.

: Biliary tract cancers (BTCs) have distinct tumor biology but share a poor prognosis, with a 5-year-survival-rate of 5-19%. Surgical resection is the only potential cure, but recurrences are common. The role of adjuvant radiotherapy (XRT) remains unclear.

Prognostic role of geriatric nutritional risk index (GNRI) and controlling nutritional status (CONUT) on outcomes in patients with head and neck cancer: a systematic review and meta-analysis.

Background: Malnutrition is a common comorbidity in patients with head and neck cancer (HNC), significantly impacting survival rates. The Geriatric Nutritional Risk Index (GNRI) and the Controlling Nutritional Status (CONUT) score are tools used to assess the nutritional status, yet their prognostic value in HNC remains to be fully established.

Methods: We performed a systematic review and meta-analysis, adhering to PRISMA guidelines, to evaluate the prognostic significance of GNRI and CONUT on survival outcomes in patients with HNC.

Frequency, cost, and time to re-treatment after active periodontal therapy.

Background: Supportive periodontal therapy (SPT) reduces the probability of infection reoccurrence further disease progression. Despite that, several patient/tooth related variables have been linked to tooth loss during SPT. This longitudinal study examines the correlation between periodontal staging, grading, initial therapy, and frequency, cost, and time-to-re-treatment following active periodontal therapy (APT).

Stem Cell-Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies.

Stroke, a neurological condition from compromised cerebral blood perfusion, remains a major global cause of mortality and disability. Conventional therapies like tissue plasminogen activator are limited by narrow therapeutic windows and potential adverse effects, highlighting the urgency for novel treatments. Stem cell-based therapies, with their neuroprotective and regenerative properties, present a promising yet highly diverse alternative.

Development and initial validation of a role strain scale for male nursing students.

Background: Male nursing students face numerous challenges in learning and clinical practice due to occupational gender segregation and societal gender stereotypes. Although there is a role strain scale for nursing students of both genders, it is not specifically designed to assess role strain in areas such as community, family, peers, and nursing education among male nursing students.

Purpose: To develop and initially validate a Role Strain Scale for male nursing students.

Effects of osteoporosis treatment and multicomponent integrated care on intrinsic capacity and happiness among rural community-dwelling older adults: the Healthy Longevity and Ageing in Place (HOPE) randomised controlled trial.

Background: Monitoring and improving intrinsic capacity (IC) and well-being are essential for older adults to maintain functional abilities. However, evidence of effective interventions to improve IC and happiness is scarce. This study examined the effects of multicomponent interventions in the Healthy Longevity and Ageing in Place (HOPE) randomised controlled trial on IC and happiness among rural community-dwelling older adults.

Postacute COVID-19 fatigue, dyspnea and reduced activity in children and adolescents.

Background: This study aimed to quantify fatigue, dyspnea, and physical activity and identify associated factors in children and adolescents with postacute COVID-19 syndrome.

Methods: A prospective cohort study included 74 participants aged 6-18 years with postacute COVID-19 symptoms and 120 age- and sex-matched controls without SARS-CoV-2 antibodies. Participants completed questionnaires assessing fatigue, dyspnea, and physical activity and underwent pulmonary function tests.

Assessment of genetic conservation units of an endangered glacial relict insular species, , based on fine-scale genetic structures of multiple fragmented mountainous populations in Taiwan.

Insular species are usually endemic and prone to long-term population reduction, low genetic diversity, and inbreeding depression, which results in difficulties in species conservation. The situation is even more challenging for the glacial relict species whose habitats are usually fragmented in the mountainous regions. is an endangered and endemic relict tree species in Taiwan.

The impact of interfacial quality and nanoscale performance disorder on the stability of alloyed perovskite solar cells.

Microscopy provides a proxy for assessing the operation of perovskite solar cells, yet most works in the literature have focused on bare perovskite thin films, missing charge transport and recombination losses present in full devices. Here we demonstrate a multimodal operando microscopy toolkit to measure and spatially correlate nanoscale charge transport losses, recombination losses and chemical composition. By applying this toolkit to the same scan areas of state-of-the-art, alloyed perovskite cells before and after extended operation, we show that devices with the highest macroscopic performance have the lowest initial performance spatial heterogeneity-a crucial link that is missed in conventional microscopy.

Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer.

Background: The homologous recombination deficiency (HRD) test is an important tool for identifying patients with epithelial ovarian cancer (EOC) benefit from the treatment with poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi). Using whole exome sequencing (WES)-based platform can provide information of gene mutations and HRD score; however, the clinical value of WES-based HRD test was less validated in EOC.

Methods: We enrolled 40 patients with EOC in the training cohort and 23 in the validation cohort.

Caps-ac4C: An effective computational framework for identifying N4-acetylcytidine sites in human mRNA based on deep learning.

N4-acetylcytidine (ac4C) is a crucial post-transcriptional modification in human mRNA, involving the acetylation of the nitrogen atom at the fourth position of cytidine. This modification, catalyzed by N-acetyltransferases such as NAT10, is primarily found in mRNA's coding regions and enhances translation efficiency and mRNA stability. ac4C is closely associated with various diseases, including cancer.

Predicting Survival Outcomes for Patients with Ovarian Cancer Using National Cancer Registry Data from Taiwan: A Retrospective Cohort Study.

Background: Ovarian cancer is one of the top seven causes of cancer deaths. Incidence of ovarian cancer varies by ethnicity, where Asian women demonstrate lower incidence rates than non-Hispanic Blacks and Whites. Survival prediction models for ovarian cancer have been developed for Caucasians and Black populations using national databases; however, whether these models work for Asians is unclear.