Publications by authors named "Chiaki Takehisa"
Article Synopsis
- Cellular senescence leads to an irreversible halt in cell growth and negatively impacts the tissue environment, particularly in the uterus where it can contribute to preterm delivery.
- Previous research showed an increase in senescent cells in mouse uteri during pregnancy, and the new study highlighted that these cells decrease postpartum, aided by macrophages around their accumulation sites.
- When macrophages were depleted, an increase in senescent cells was observed, and mice lacking the p53 gene showed further imbalances in macrophage types, more senescent cells, and poorer pregnancy outcomes, underscoring the role of macrophages in removing senescent cells to support uterine health post-delivery.
