Development of an Assessment Tool to Measure the Quality of Life Goal Setting for Cancer Survivors: A Content Validity Study.

Introduction: An initial version of the Reengagement Life Goal Assessment Tool for Cancer Survivors (ReGAT-C) was designed to measure the quality of life goal-setting practice conducted by responsible healthcare professionals along with nonterminal cancer survivors undergoing inpatient cancer treatment. This study aimed to test content validity of the ReGAT-C and revise it.

Methods: Eleven experts and nine healthcare professionals participated in this study.

Dimethyl Fumarate Induces Apoptosis via Inhibition of NF-κB and Enhances the Effect of Paclitaxel and Adriamycin in Human TNBC Cells.

Triple-negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes. Recently, the activation of NF-κB, which is involved in the growth and survival of malignant tumors, has been demonstrated in TNBC, suggesting that NF-κB may serve as a new therapeutic target. In the present study, we examined whether dimethyl fumarate (DMF), an NF-κB inhibitor, induces apoptosis in TNBC cells and enhances the apoptosis-inducing effect of paclitaxel and adriamycin.

The Relationship of Dry Eye Disease with Depression and Anxiety: A Naturalistic Observational Study.

Purpose: In recent years, the relationship between dry eye disease (DED) and psychiatric disorders has been gaining attention. The relationship between dry eye symptoms and psychiatric symptoms has been reported in multiple retrospective studies. However, in previous studies there have been limitations to these observations, such as a lack of close examination of either DED or mood symptoms.

Effects of a perilymphatic fistula on the passive vibration response of the basilar membrane.

In this study, a three-dimensional finite-element model of the passive human cochlea was created. Dynamic behavior of the basilar membrane caused by the vibration of the stapes footplate was analyzed considering a fluid-structure interaction with the cochlear fluid. Next, the effects of a perilymphatic fistula (PLF) on the vibration of the cochlea were examined by making a small hole on the wall of the cochlea model.