P-Doped NiFe Alloy-Based Oxygen Evolution Electrocatalyst for Efficient and Stable Seawater Splitting and Organic Electrosynthesis at Neutral pH.

Development of high-performance and inexpensive electrocatalysts for oxygen evolution reaction (OER) at neutral pH is important for direct seawater splitting and organic electrosynthesis but remains challenging due to the sluggish OER kinetics and diverse side reactions inherent to the constituents of working electrolytes. Herein, we report on a P:NiFe electrode, containing P-doped NiFe alloy, as an excellent electrocatalyst for hydrogen evolution reaction (HER) and OER pre-catalyst for efficient OER in both seawater and organic electrolyte for adiponitrile (ADN) electrosynthesis at neutral pH. Fe and P species modulate the coordination environment of nickel sites, which enables the simultaneous formation of OER-active nickel species and FePO passivation layer, thus transforming HER-active P:NiFe to OER-active a-P:NiFe.

Applications of three-dimensional whey protein amyloid fibril-based hybrid aerogels in oil/water separation and emulsion separation.

Environmental contamination from oil spills and industrial wastewater poses long-term risks to ecosystems and human health. Amyloid fibrils' superior stiffness and stability, outstanding biocompatibility and biodegradability, versatile functional groups, and high specific surface area make them promising sustainable adsorbents. This study is aimed at examining the application of three-dimensional polysaccharide-modified whey protein amyloid fibril (WPIAF) aerogels in oil/water separation and emulsion separation.

Efficacy of N-acetylcysteine for patients with depression: An updated systematic review and meta-analysis.

Background: Results on whether N-acetylcysteine (NAC) ameliorates depression in patients with psychiatric problems, such as bipolar disorder and major depressive disorder, remain inconsistent, and several new studies have recently been published. Thus, we conducted an uptodated meta-analysis to evaluate the efficacy of NAC against depression.

Methods: This systematic review and meta-analysis included randomized controlled trials where NAC was used to treat depression.

Bismuth-based electrocatalytic scheme enabling efficient and selective electrosynthesis of 4-aminophenol in acidic media.

A highly efficient electrocatalytic platform based on formed metallic bismuth submicron crystals (Bi) was developed for 4-aminophenol electrosynthesis the electrochemical reduction of 4-nitrophenol at acidic pH. The facile formation and high reactivity of Bi enable efficient electrosynthesis of 4-aminophenol with high selectivity (∼100%) at the expense of an ultra-low overpotential.

MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression.

The relationship between metastasis-associated protein 2 (MTA2) overexpression and tumor growth and metastasis has been extensively studied in a variety of tumor cells but not in human osteosarcoma cells. This study aims to elucidate the clinical significance, underlying molecular mechanisms, and biological functions of MTA2 in human osteosarcoma and . Our results show that MTA2 was elevated in osteosarcoma cell lines and osteosarcoma tissues and was associated with tumor stage and overall survival of osteosarcoma patients.

Using High-Resolution Vessel Wall Magnetic Resonance Images in a Patient of Intracranial Artery Dissection Related Acute Infarction.

Acute ischemic stroke in young adults typically carries significant implications for morbidity, mortality, and long-term disability. In this study, we describe the case of a 34-year-old male with no prior medical history who presented with symptoms of right-sided weakness and slurred speech, suggesting an acute ischemic stroke. Initial CT angiography revealed an occlusion in the left M2 segment middle cerebral artery (MCA).

Impact of sarcopenia on outcomes following lumbar spine surgery for degenerative disease: an updated systematic review and meta-analysis.

Purpose: This study aimed to consolidate the evidence regarding the prognostic influence of sarcopenia in degenerative lumbar spine surgeries.

Methods: A literature search of public databases was conducted up to Nov 15, 2023 using combinations of the key words "sarcopenia" and "lumbar spine surgery". Eligible studies were those that focused on adults undergoing decompression or fusion surgery for degenerative lumbar spine diseases, and compared the outcomes between patients with and without preoperative sarcopenia.

Screening and rational identification of a novel angiotensin-converting enzyme C-domain inhibitory peptide from Fabaceae food peptide library.

Angiotensin-converting enzyme (ACE), consisting of N-domain and C-domain, is a key regulator of blood pressure. The use of cACE-specific inhibitors helps minimize side effects in clinical applications. Legumes are a good source of proteins containing ACE inhibitory peptides; however, no studies have reported the identification of cACE-specific inhibitory peptides from Fabaceae.

3D-Printed proangiogenic patches of photo-crosslinked gelatin and polyurethane hydrogels laden with vascular cells for treating vascular ischemic diseases.

Engineering vascularized tissues remains a promising approach for treating ischemic cardiovascular diseases. The availability of 3D-bioprinted vascular grafts that induce therapeutic angiogenesis can help avoid necrosis and excision of ischemic tissues. Here, using a combination of living cells and biodegradable hydrogels, we fabricated 3D-printed biocompatible proangiogenic patches from endothelial cell-laden photo-crosslinked gelatin (EC-PCG) bioink and smooth muscle cell-encapsulated polyurethane (SMC-PU) bioink.

Hemophagocytic syndrome in A patient of upper urinary tract urothelial cancer after Bacillus Calmette-Guérin instillation: A case report.

Bacillus Calmette-Guérin (BCG) therapy is an adjuvant treatment for urothelial carcinomas of the upper urinary tract (UTUC). BCG therapy can result in various side effects. We present a case of a 67-year-old female with a history of UTUC who developed disseminated tuberculosis following BCG instillation into the upper urinary tract after conservative management.

Selective activation of IFNγ-ipilimumab enhances the therapeutic effect and safety of ipilimumab.

Introduction: Immune checkpoint inhibitor therapy is a highly promising strategy for clinical treatment of cancer. Among these inhibitors, ipilimumab stands out for its ability to induce cytotoxic T cell proliferation and activation by binding to CTLA-4. However, ipilimumab also gives rise to systemic immune-related adverse effects and tumor immune evasion, limiting its effectiveness.

Navigation-Assisted One-Staged Posterior Spinal Fusion Using Pedicle Screw Instrumentation in Adolescent Idiopathic Scoliosis-A Case Series.

: Adolescent idiopathic scoliosis (AIS) is a prevalent three-dimensional spinal disorder, with a multifactorial pathogenesis, including genetics and environmental aspects. Treatment options include non-surgical and surgical treatment. Surgical interventions demonstrate positive outcomes in terms of deformity correction, pain relief, and improvements of the cardiac and pulmonary function.

Classification Prediction of Alzheimer's Disease and Vascular Dementia Using Physiological Data and ECD SPECT Images.

Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common forms of dementia. However, their neuropsychological and pathological features often overlap, making it difficult to distinguish between AD and VaD. In addition to clinical consultation and laboratory examinations, clinical dementia diagnosis in Taiwan will also include Tc-99m-ECD SPECT imaging examination.

Unraveling the Effect of Stereoisomerism on Mobility-Stretchability Properties of -Type Semiconducting Polymers with Biobased Epimers as Conjugation Break Spacers.

The development of intrinsically stretchable -type semiconducting polymers has garnered much interest in recent years. In this study, three biobased dianhydrohexitol epimers of isosorbide (), isomannide (), and isoidide (), derived from cellulose, were incorporated into the backbone of a naphthalenediimide (NDI)-based -type semiconducting polymer as conjugation break spacers (CBSs). Accordingly, three polymers were synthesized through the Migita-Kosugi-Stille coupling polymerization with NDI, bithiophene, and CBSs, and the mobility-stretchability properties of these polymers were investigated and compared with those of their analogues with conventional alkyl-based CBSs.

Selective electrosynthesis of platform chemicals from the electrocatalytic reforming of biomass-derived hexanediol.

6-Hydroxyhexanoic acid and adipic acid are platform chemicals and are widely used as building blocks for the synthesis of important polymers. Nevertheless, the industrial syntheses of these two chemicals are fossil fuel-based and involve the use of corrosive acid and emission of the NO greenhouse gas. In this study, the electrosynthesis of 6-hydroxyhexanoic acid and adipic acid from the electrochemical oxidation of hexanediol at the nanoporous nickel oxyhydroxide modified electrode was explored as an environmentally-benign alternative to the industrial syntheses of 6-hydroxyhexanoic acid and adipic acid.

Chub movement is attracted by the collision sounds associated with spawning activities.

Cyprinids (carps, chubs and minnows) possess well-developed hearing and high sensitivity to sound pressure. The sensitive hearing may assist cyprinids with searching for food, territory defense, and mating behavior. Many paired fishes violently shake in sand and gravel while spawning in rivers.

Factors Deciding Conservative or Intervention Treatment for Prostate Abscess: A Retrospective Case-Control Study.

Prostate abscess (PA) can lead to severe urosepsis and septic shock if not treated promptly. However, early diagnosis can be hindered by the declining incidence of PA, especially in developing countries and high-risk patients. Despite the prevalence of PA, there is currently a lack of well-established contemporary guidelines or treatment algorithms.

Tracking auditory mismatch negativity responses during full conscious state and coma.

The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, we tracked auditory MMN responses in seventeen healthy controls over a 12-h period, and in three comatose patients assessed over 24 h at two time points. We investigated whether the MMN responses show fluctuations in detectability over time in full conscious awareness, or whether such fluctuations are rather a feature of coma.