Ultrasensitive Assays Detect Different Conformations of Plasma β Amyloids.

With the developments of ultrasensitive technologies such as immunomagnetic reduction (IMR) assay, single molecule array (SIMOA) assay, electrochemiluminescence immunoassay (ECLIA), the assay of blood-based amyloid 1-42 (Aβ) becomes possible. However, the changes in measured plasma Aβ concentrations in Alzheimer's disease (AD) compared to cognitively unimpaired subjects (CU) are inconsistent. A possible reason for the inconsistency regarding various conformations of Aβ in plasma is explored in this study.

Correlation between Orientation Spread and Ear Forming of As-Annealed AA5151 Aluminum Alloy.

In the present work, we take the influences of activated slip systems and the orientation spread into account to predict the cup height using analytical earing models and compare the predicted results with experimental results. The effect of boundary conditions of the various stress states and the work hardening exponents are compared and discussed for profile of single crystals. A stress ratio of -0.

Relationships of social support and attitudes towards death: A mediator role of depression in older patients on haemodialysis.

Aim: To explore the mediating role of depression in older people receiving haemodialysis on social support and the attitude of participants towards death.

Design: A cross-sectional questionnaire survey.

Methods: Data were collected from older people undergoing dialysis (N = 209) at two regional hospitals in the north of Taiwan.

Spiritual well-being of patients with chronic renal failure: A cross-sectional study.

Aims: The study aimed to investigate the relationship among physical symptom distress, sleep quality, depression and spiritual well-being of patients with chronic renal failure (CRF) and analyse the predictors of the spiritual well-being.

Design: A cross-sectional study.

Methods: A total of 188 patients were selected.

Juniperus communis extract induces cell cycle arrest and apoptosis of colorectal adenocarcinoma in vitro and in vivo.

Juniperus communis (JCo) is a well-known traditional Chinese medicinal plant that has been used to treat wounds, fever, swelling, and rheumatism. However, the mechanism underlying the anticancer effect of JCo extract on colorectal cancer (CRC) has not yet been elucidated. This study investigated the anticancer effects of JCo extract in vitro and in vivo as well as the precise molecular mechanisms.

extract as an anticancer agent on human acute myeloid leukemia.

has been indicated to treat many kinds of diseases and the progression of cancers, such as colorectal cancer. However, the effects of extract (PPa extract) against acute myeloid leukemia have not been investigated. Thus, this study explored the anticancer potential of PPa extract and its mechanism in HL-60 cells.

Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: and Studies.

Glioblastoma (GBM) is the most common malignant primary brain tumor in humans, exhibiting highly infiltrative growth and drug resistance to conventional chemotherapy. (CAt) extract has been shown to decrease postoperative pain and inhibit the growth of K562 leukemia cells. The aim of this study was to assess the anti-GBM activity and molecular mechanism of CAt extract and .

The Anti-inflammatory Effects of the Bioactive Compounds Isolated from Hance Mediated by the Suppression of NF-kappaB and MAPK Signaling.

This study was designed to evaluate the anti-inflammatory effects of Alpinia officinarum Hance extract (AOE) and identify its main active ingredients. AOE was obtained using a 95% ethanol extraction method. Lipopolysaccharide (LPS) were used to induce an inflammatory response in RAW264.

Cell cycle arrest and apoptosis induction by extract in esophageal squamous cell carcinoma through activation of p53-induced apoptosis pathway.

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers. It has a high mortality rate and requires novel effective drugs and therapeutic approaches. (JCo), used to flavor gin and food, has been documented to have anti-tumor activity.

Extract Derived from Acts as an Antitumor Agent on Hepatocellular Carcinoma Growth In Vitro and In Vivo.

is widely used in herbal medicine. However, the anti-cancer activity of extract (CAt extract) has not been clarified in hepatocellular carcinoma. In the study, we elucidated the anti-hepatoma capacity of CAt extract on HCC in vitro and in vivo.

Extract of Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade.

Oral cancer-a type of head and neck cancer-is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed.

CO-releasing molecules and increased heme oxygenase-1 induce protein S-glutathionylation to modulate NF-κB activity in endothelial cells.

Protein glutathionylation is a protective mechanism that functions in response to mild oxidative stress. Carbon monoxide (CO) can increase the reactive oxygen species concentration from a low level via the inhibition of cytochrome c oxidase. We therefore hypothesized that CO would induce NF-κB-p65 glutathionylation and then show anti-inflammatory effects.

Influence of high temperature during grain filling on the accumulation of storage proteins and grain quality in rice (Oryza sativa L.).

The present study was performed to understand the effects of high temperature (HT) during filling on the expression of storage proteins and the quality of rice grains. HT (35/30 °C day/night) reduced the weight, amylose content, and flour gel consistency of grains. It increased the accumulation of all classes of storage proteins at early filling stage but decreased the accumulation of prolamins at maturation.