Publications by authors named "Chia-Yu Chang"

Canine mammary tumor (CMT) is a prevalent and destructive disease often diagnosed at an advanced stage, leading to poor outcomes. Currently, there is a lack of effective biomarkers for early detection and prognostic prediction of CMT. To improve CMT detection, we established a multiplexed immunoassay using a fluorescence bead-based suspension array system to measure serum levels of autoantibodies against four CMT-associated proteins (AGR2, HAPLN1, IGFBP5, and TYMS) in CMT patients.

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Bacterial infection risk in work environments has been extensively reported for healthcare workers, while this risk is rarely researched in other occupations. This study aimed to identify occupational environments in Taiwan's agricultural and healthcare industries with elevated bacterial infection risks by comparing risks for general bacterial infections and pneumonia. Using labour and health insurance claim data from 3.

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Efficient and robust electrocatalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are crucial for fuel cells, metal-air batteries, and other energy technologies. Here, a highly stable, efficient bifunctional OER/ORR electrocatalyst (FeNi-NC@MWCNTs) is reported and demonstrated its integration and robust performance in an aqueous Zinc-air battery (ZAB). The catalyst is based on neighboring iron/nickel sites (FeNiN) which are atomically dispersed on porous nitrogen-doped carbon particles.

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There are currently over forty degenerative diseases that are correlated with abnormal accumulation of peptide/protein aggregates in the human body, such as Alzheimer's disease. Due to their unique physiochemical properties (e.g.

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Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that causes muscle atrophy and primarily targets motor neurons (MNs). Approximately 20% of familial ALS cases are caused by gain-of-function mutations in superoxide dismutase 1 (SOD1), leading to MN degeneration and ion channel dysfunction. Previous studies have shown that n-Butylidenephthalide (BP) delays disease progression and prolongs survival in animal models of ALS.

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Article Synopsis
  • Rechargeable zinc-air batteries (RZABs) are promoted as efficient energy storage solutions due to their high energy density and safety features, but they require effective electrocatalysts to enhance oxygen reactions.
  • The study develops high-entropy Prussian blue analogues (HEPBAs) that improve stability and functionality by mixing various metals, allowing the creation of complex multiphase nanoparticles with two active sites for oxygen reactions.
  • The optimized HEPBA/CNT nanoparticles show superior performance in energy storage, achieving an open-circuit voltage of 1.39 V, excellent stability over 40 hours of cycles, and an impressive energy density of 71 mW/cm², suggesting a promising direction for sustainable battery technology.
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Proper organ functioning relies on adequate blood circulation; thus, monitoring blood flow is crucial for early disease diagnosis. Laser speckle contrast imaging (LSCI) is a noninvasive technique that is widely used for measuring superficial blood flow. In this study, we developed a portable LSCI system using an 805-nm near-infrared laser and a monochrome CMOS camera with a 10 × macro zoom lens.

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Designing hybrid transition metal phosphosulfide electrocatalysts is critical for the hydrogen evolution reaction (HER). We propose a novel approach by designing a hierarchical structure of cobalt phosphide (CoP) and nickel phosphide (NiP) nanoparticles topotactically developed on nickel sulfide (NiS) nanorods (CoNiP/NiS) a sulfuration-phosphorization strategy using conductive 3D nickel foam. Hierarchical heterostructured nanorods were achieved without the need for template removal steps or the assistance of surfactants.

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Electrochemical approaches for generating hydrogen from water splitting can be more promising if the challenges in the anodic oxygen evolution reaction (OER) can be harnessed. The interface heterostructure materials offer strong electronic coupling and appropriate charge transport at the interface regions, promoting accessible active sites to prompt kinetics and optimize the adsorption-desorption of active species. Herein, we have designed an efficient multi-interface-engineered NiFe LDH/NiS/TW heterostructure on in situ generated titanate web layers from the titanium foam.

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RNA bacteriophage MS2-derived virus-like particles (VLPs) have been widely used in biomedical research as model systems to study virus assembly, structure-function relationships, vaccine development, and drug delivery. Considering the diverse utility of these VLPs, a systemic engineering approach has been utilized to generate smaller particles with optimal serum stability and tissue penetrance. Additionally, it is crucial to demonstrate the overall stability of these mini MS2 VLPs, ensuring cargo protection until they reach their target cell/organ.

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African swine fever (ASF) is a deadly disease of swine currently causing a worldwide pandemic, leading to severe economic consequences for the porcine industry. The control of disease spread is hampered by the limitation of available effective vaccines. Live attenuated vaccines (LAVs) are currently the most advanced vaccine prototypes, providing strong protection against ASF.

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Drugs that can treat one disease may either be detrimental or beneficial toward another due to possible cross-interactions. Therefore, care in choosing a suitable drug for patients with multiple diseases is crucial in successful patient management. This study explores several currently available ophthalmic drugs used to treat common ocular diseases to understand how they can affect the amyloidogenesis of a transforming growth factor β-induced protein (TGFBIp) peptide fragment found in abundance in the corneal protein aggregation deposits of lattice corneal dystrophy (LCD) patients.

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Conventional non-fullerene acceptors (NFAs) typically have planar structures that can enable improved electron mobility and produce more efficient organic photovoltaic devices. A relatively simple A-D-A'-D-A type NFA specifically designed to match with poly(3-hexylthiophene-2,5-diyl) (P3HT) for green-absorbing agrivoltaic applications has been examined using a variety of techniques: microsecond transient absorption spectroscopy, atomic force microscopy, and photoluminescence. Relatively invariant charge carrier decay dynamics are observed in the blend films across a variety of processing solvents.

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Introduction: Over 75% of clinical microbiological infections are caused by bacterial biofilms that grow on wounds or implantable medical devices. This work describes the development of a new poly(diallyldimethylammonium chloride) (PDADMAC)/alginate-coated gold nanorod (GNR/Alg/PDADMAC) that effectively disintegrates the biofilms of (), a prominent pathogen responsible for hospital-acquired infections.

Methods: GNR was synthesised via seed-mediated growth method, and the resulting nanoparticles were coated first with Alg and then PDADMAC.

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The use of the "Holy Grail" lithium metal anode is pivotal to achieve superior energy density. However, the practice of a lithium metal anode faces practical challenges due to the thermodynamic instability of lithium metal and dendrite growth. Herein, an artificial stabilization of lithium metal was carried out via the thermal pyrolysis of the NHF salt, which generates HF(g) and NH(g).

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Article Synopsis
  • * A new nanoparticle named VP28-heparin was developed by conjugating heparin with an immuno-stealth protein, showcasing promising properties such as non-immunogenicity and a size that helps it evade rapid removal from circulation.
  • * In tests, VP28-heparin demonstrated improved anticoagulation effects compared to traditional heparin without negatively impacting platelet counts or causing severe side effects, making it a potentially safer therapeutic option.
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Bacteria-based cancer therapy employs various strategies to combat tumors, one of which is delivering tumor-associated antigen (TAA) to generate specific immunity. Here, we utilized a poly-arginine extended HPV E7 antigen (9RE7) for attachment on Salmonella SL7207 outer membrane to synthesize the bacterial vaccine Salmonella-9RE7 (Sal-9RE7), which yielded a significant improvement in the amount of antigen presentation compared to the previous lysine-extended antigen coating strategy. In TC-1 tumor mouse models, Sal-9RE7 monotherapy decreased tumor growth by inducing E7 antigen-specific immunity.

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Currently, hydrogen peroxide (HO) manufacturing involves an energy-intensive anthraquinone technique that demands expensive solvent extraction and a multistep process with substantial energy consumption. In this work, we synthesized Pd-N-CO, Pd-S-NCO, and Pd-NO-C single-atom catalysts via an in situ synthesis approach involving heteroatom-rich ligands and activated carbon under mild reaction conditions. It reveals that palladium atoms interact strongly with heteroatom-rich ligands, which provide well-defined and uniform active sites for oxygen (O) electrochemically reduced to hydrogen peroxide.

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Polyethylene terephthalate (PET) is favored for its exceptional properties and widespread daily use. This review highlights recent advancements that enable the development of biological tools for PET decomposition, transforming PET into valuable platform chemicals and materials in upcycling processes. Enhancing PET hydrolases' catalytic activity and efficiency through protein engineering strategies is a priority, facilitating more effective PET waste management.

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Despite the unique advantages of single-atom catalysts, molecular dual-active sites facilitate the C-C coupling reaction for C products toward the CO reduction reaction (CORR). The Ni/Cu proximal dual-active site catalyst (Ni/Cu-PASC) is developed, which is a harmonic catalyst with dual-active sites, by simply mixing commercial Ni-phthalocyanine (Ni-Pc) and Cu-phthalocyanine (Cu-Pc) molecules physically. According to scanning transmission electron microscopy (STEM) and transmission electron microscopy (TEM) energy dispersive spectroscopy (EDS) data, Ni and Cu atoms are separated, creating dual-active sites for the CORR.

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Common fragile sites (CFSs) are regions prone to chromosomal rearrangements, thereby contributing to tumorigenesis. Under replication stress (RS), CFSs often harbor under-replicated DNA regions at the onset of mitosis, triggering homology-directed repair known as mitotic DNA synthesis (MiDAS) to complete DNA replication. In this study, we identified an important role of DNA mismatch repair protein MutSβ (MSH2/MSH3) in facilitating MiDAS and maintaining CFS stability.

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As a crucial stage of electrochemical water splitting, hydrogen evolution reaction (HER) favour catalyst to attain rapid kinetics for its broader application, alternating Pt in the acidic environment. Transition metal phosphides (TMPs) are one kind of earth-abundant, nonprecious-based catalyst which has been classified as a viable alternative and active for HER. While the performance remains inferior to Pt which primarily targets durability under high current density, pinpointing the reconfiguration strategy would be critical to their catalytic competency.

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Ethnopharmacological Relevance: Orthosiphon aristatus (Blume) Miq. (OA) is a traditional folk-herb, which is usually used to treat acute and chronic nephritis, epilepsy, cystitis, and other diseases. Phenols and flavonoids are the main active compound compounds of OA, with proven anti-inflammatory and antioxidant activities.

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