Publications by authors named "Chia-Yin Chien"
Hospital-acquired infections (HAIs) are serious complication for patients with acute ischemic stroke (AIS), often resulting in poor functional outcomes. However, no existing model can specifically predict HAI in AIS patients. Therefore, we employed the Gradient Boosting matching learning algorithm to establish predictive models for HAI occurrence in AIS patients and poor 30-day functional outcomes (modified Rankin Scale > 2) in AIS patients with HAI by analyzing electronic health records from 6560 AIS patients.
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- - The study focuses on myasthenia gravis (MG) patients experiencing myasthenic crises (MC) triggered by infections, highlighting a gap in prognostic factors for recurrent MC, which can worsen patient outcomes.
- - A total of 272 MG patients were analyzed, revealing that older patients and those with certain comorbidities, such as diabetes and specific electrolyte imbalances, are more likely to face recurrent infections.
- - Key findings indicated that pneumonia was the most common infection and identified various associated risk factors for recurrent infection-triggered MC, which can aid clinicians in tailoring prevention strategies.
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder that primarily affects the white matter of central nervous system and the adrenal cortex. It is caused by mutations in the adenosine triphosphate-binding cassette, subfamily D, member 1 (ABCD1) gene that results in elevated plasma levels of very long chain fatty acids (VLCFAs). The disease is characterized by an unpredictable variation in phenotypic expressions, including childhood cerebral form (CCALD) and adrenomyeloneuropathy (AMN).
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