Autologous platelet-rich plasma treatment for moderate-severe Asherman syndrome: the first experience.

Purpose: Treatment of Asherman syndrome (AS) presents a significant clinical challenge. Based on our in vitro data showing that PRP could activate endometrial cell proliferation and migration, we hypothesized that intrauterine infusion of autologous platelet-rich plasma (PRP) may improve endometrial regeneration and fertility outcomes in patients with moderate-severe AS.

Materials And Methods: Subjects with moderate-severe AS were randomized to PRP or saline control administered following hysteroscopic adhesiolysis.

Assessing the impact of semen quality on embryo development in an egg donation model.

Objective: To investigate if any of the World Health Organization semen parameters and/or male age are associated with embryo development.

Design: Retrospective chart review between January 2008 and May 2015.

Setting: Academic fertility practice.

Comparison of metabolic syndrome elements in White and Asian women with polycystic ovary syndrome: results of a regional, American cross-sectional study.

Objective: To examine differences in metabolic dysfunction between White, East Asian, and South Asian women with polycystic ovary syndrome (PCOS) living in the San Francisco Bay Area, California.

Design: Cross-sectional study.

Setting: Referral clinic at an academic center.

Predictors of adequate physical activity within a multiethnic polycystic ovary syndrome patient population: a cross-sectional assessment.

Background: Physical activity is a cornerstone for treatment of women with polycystic ovary syndrome (PCOS), but there are limited data on their exercise behaviors. A previous study identified PCOS patients of non-White ethnicity to be at higher risk for inadequate physical activity. Further data is needed to identify groups that would benefit from additional counseling in achieving adequate physical activity (APA).

Effect of culture conditions and method of conception on mouse live birth rate.

Objective: To understand in a mouse model whether there are differences in the decidua and live birth rate after transfer of blastocysts generated by in vitro fertilization (IVF) or by superovulation with spontaneous mating into unstimulated recipients.

Design: Animal experiment.

Setting: University-affiliated tertiary hospital.

Improved diagnostic performance for the diagnosis of polycystic ovary syndrome using age-stratified criteria.

Objective: To determine optimal criteria for polycystic ovary morphology.

Design: Cross-sectional study.

Setting: Multidisciplinary polycystic ovary syndrome (PCOS) clinic at a tertiary academic center.

Semen Parameters Among Transgender Women With a History of Hormonal Treatment.

Objective: To report on the semen quality parameters in transgender women who pursued semen cryopreservation either in the presence or absence of gender-affirming hormonal medication.

Materials And Methods: This retrospective cohort study was conducted as a chart review of consecutive transgender women presenting for semen cryopreservation between January 1, 2012 and March 31, 2018. Demographic data and semen parameters were assessed.

Impact of the levonorgestrel-releasing intrauterine device on controlled ovarian stimulation outcomes.

Objective: To report differences in ovarian stimulation outcomes in women using a levonorgestrel-releasing intrauterine device (LNG-IUD).

Design: Retrospective cohort study.

Setting: University-based infertility practice.

Differential rate in decline in ovarian reserve markers in women with polycystic ovary syndrome compared with control subjects: results of a longitudinal study.

Objective: To estimate rates of ovarian aging in polycystic ovary syndrome (PCOS) subjects versus a community control population.

Design: Longitudinal.

Setting: Tertiary academic center.

Antimüllerian hormone levels and antral follicle counts are not reduced compared with community controls in patients with rigorously defined unexplained infertility.

Objective: To test the hypothesis that women with unexplained infertility demonstrate evidence of diminished ovarian reserve when compared with a population of community controls.

Design: Cross-sectional study.

Setting: Multicenter university-based clinical practices.

Women with polycystic ovary syndrome demonstrate worsening markers of cardiovascular risk over the short-term despite declining hyperandrogenaemia: Results of a longitudinal study with community controls.

Objective: To compare age-associated changes in cardiovascular risk markers in lean and obese reproductive-aged women with polycystic ovary syndrome (PCOS) with community controls.

Design: Longitudinal study at an academic medical centre PATIENTS: Patients diagnosed with PCOS by 2004 Rotterdam criteria in a multidisciplinary clinic were systematically enrolled from 2006-2014 in a PCOS cohort study and subsequently agreed to participate in a longitudinal study. The comparison controls were from the prospective, longitudinal Ovarian Aging (OVA) study, which consists of healthy women with regular menstrual cycles recruited from 2006 to 2011.

Age-stratified thresholds of anti-Müllerian hormone improve prediction of polycystic ovary syndrome over a population-based threshold.

Objective: Due to its consistent elevation in polycystic ovary syndrome (PCOS) and correlation with polycystic ovarian morphology (PCOM), anti-Mullerian hormone (AMH) has been proposed as a marker of the syndrome. However, prior studies reporting thresholds of AMH for a PCOS diagnosis have been limited by small sample size, inappropriate controls, and heterogeneous AMH assays. We sought to evaluate the suitability of a standardized AMH assay as a biomarker of PCOS.

Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.

Background: Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk.

Raising threshold for diagnosis of polycystic ovary syndrome excludes population of patients with metabolic risk.

Objective: To characterize the population of patients excluded from a diagnosis of polycystic ovary syndrome (PCOS) when follicle number criteria are increased to 25 per ovary as suggested by the Androgen Excess and Polycystic Ovary Syndrome Society's recent task force.

Design: Cross-sectional study.

Setting: Tertiary academic center.

Impact of pituitary suppression on antral follicle count and oocyte recovery after ovarian stimulation.

Objective: To investigate the potential influence of short-term pituitary suppression on antral follicle count (AFC) and correlate the AFC with the number of oocytes retrieved after ovarian stimulation.

Design: Retrospective study.

Setting: University fertility center.

Vigorous exercise is associated with superior metabolic profiles in polycystic ovary syndrome independent of total exercise expenditure.

Objective: To characterize metabolic features of women with polycystic ovary syndrome (PCOS) by exercise behavior and determine relative health benefits of different exercise intensities.

Design: Cross-sectional study.

Setting: Tertiary academic institution.

Association of tamoxifen use and ovarian function in patients with invasive or pre-invasive breast cancer.

The impact of long-term tamoxifen therapy on ovarian function is not known. Understanding these effects will help reproductive-aged patients who desire future pregnancy make more informed decisions regarding their treatment. This is a retrospective cohort study in patients identified through the UCSF Cancer Registry and SPORE database.

Behavior and brain gene expression changes in mice exposed to preimplantation and prenatal stress.

Preimplantation culture of mouse embryos has been suggested to result in reduced anxiety-like behavior in adulthood. Here, we investigated the effects of in vitro fertilization (IVF), embryo culture, and different diets on anxiety-like behavior using the elevated plus maze (EPM). We hypothesized that exposure to suboptimal conditions during the preimplantation stage would interact with the suboptimal diet to alter behavior.

Birth weight and childhood growth in daughters of women with irregular menstrual cycles.

Menstrual irregularity has been associated with insulin resistance, type 2 diabetes mellitus and markers of metabolic dysfunction. This study aimed to determine whether irregular menstrual cycles (MCs) in reproductive-age women are associated with the weight of their daughters at birth and growth up to age five. We studied 4863 pregnant women with menstrual history data in a prospective cohort, recruited from the Kaiser Health Plan (1959-1966).

Phenotypic comparison of Caucasian and Asian women with polycystic ovary syndrome: a cross-sectional study.

Objective: To determine whether manifestations of polycystic ovary syndrome (PCOS), particularly androgen excess, differ between Caucasian and Asian women in the San Francisco Bay Area.

Design: Cross-sectional study.

Setting: Multidisciplinary PCOS clinic at a tertiary academic center.