The novel HLA class I allele HLA-C*07:02:81 differs from HLA-C*07:02:01:01 by a synonymous mutation.

HLA-C*07:02:81 differs from HLA-C*07:02:01:01 by one nucleotide substitution at position 465 (C→A) in exon 3.

Unraveling RNA contribution to the molecular origins of bacterial surface-enhanced Raman spectroscopy (SERS) signals.

Surface-enhanced Raman spectroscopy (SERS) is widely utilized in bacterial analyses, with the dominant SERS peaks attributed to purine metabolites released during sample preparation. Although adenosine triphosphate (ATP) and nucleic acids are potential molecular origins of these metabolites, research on their exact contributions remains limited. This study explored purine metabolite release from E.

Five-year Maintenance of Clinical Response and Consistent Safety Profile for Guselkumab in Asian patients with Psoriasis from VOYAGE 1 and VOYAGE 2.

Introduction: Guselkumab is a human monoclonal antibody against IL-23 used in the treatment of moderate-to-severe psoriasis. This post-hoc analysis evaluated the efficacy and safety of guselkumab in the Asian subpopulation of VOYAGE 1 and VOYAGE 2 through 5 years.

Methods: The proportions of guselkumab-treated Asian patients (VOYAGE 1 and 2) achieving Psoriasis Area and Severity Index (PASI) 90 and PASI 100, Investigator's Global Assessment (IGA) scores of 0/1 and 0, and Dermatology Life Quality Index (DLQI) scores of 0/1 (week 100 through week 252) were assessed.

Discovery of the novel HLA-C*01:143N allele, a variant of HLA-C*01:02:01:01, in a Taiwanese individual.

HLA-C*01:143N differs from HLA-C*01:02:01:01 by one nucleotide substitution at position 585 (C → A) in exon 3.

The novel HLA-A*02:672Q allele, identified by Sanger dideoxy nucleotide sequencing in a Taiwanese individual.

HLA-A*02:672Q differs from HLA-A*02:06:01:01 by one nucleotide substitution at position 563 (G → A) in exon 3.

HBV genotype-dependent association of HLA variants with the serodecline of HBsAg in chronic hepatitis B patients.

Seroclearance of hepatitis B surface antigen (HBsAg) is regarded as the functional cure for chronic hepatitis B (CHB). The relationship between human leukocyte antigen (HLA) variants, hepatitis B virus genotype, and longitudinal HBsAg serodecline remains to be explored. A total of 1735 HBeAg-seronegative CHB patients with genotype B or C infection of the community-based REVEAL-HBV cohort were genotyped for rs1710 (HLA-G) and rs2770 (HLA-B) using TaqMan assay.

Gas-phase and PM-bound phthalates in nail salons: characteristics, exposure via inhalation, and influencing factors.

This study aimed to investigate the characteristics of, exposure to, and factors influencing gas-phase and PM-bound phthalates (PAEs) in nail salons. Data on both indoor and outdoor gas-phase and PM-bound PAEs, carbon dioxide (CO), temperature, and relative humidity were collected in nail salons. We also used questionnaires to survey building characteristics and occupants' behaviors.

Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems.

Blood culture is the main tool used to identify causative pathogens. Adequate volume and number of culture sets are considered key to blood culture positivity rate. It is not known whether these factors remain critical to the positivity rate after the introduction of automated continuous blood culture system monitoring.

Effectiveness and Safety of Lower Dose of Rivaroxaban for Cancer-Related Venous Thromboembolism: A Retrospective Cohort Study.

Background: Primary and recurrent venous thromboembolism (VTE) commonly occur in patients with cancer. However, because of the National Health Insurance regulations, available dosage forms, and clinical conditions, the prescribed dose of rivaroxaban may not be consistent with its recommended dose.

Objective: To evaluate the 6-month recurrence rate of VTE and safety of rivaroxaban for patients with cancer.

The Impact of the Age, Dyspnoea, and Airflow Obstruction (ADO) Index on the Medical Burden of Chronic Obstructive Pulmonary Disease (COPD).

There are currently no good indicators that can be used to predict the medical expenses of chronic obstructive pulmonary disease (COPD). This was a retrospective study that focused on the correlation between the age, dyspnoea, and airflow obstruction (ADO) index and the Charlson comorbidity index (CCI) on the medical burden in COPD patients, specifically, those of patients with complete ADO index and CCI data in our hospital from January 2015 to December 2016. Of the 396 patients with COPD who met the inclusion criteria, 382 (96.

Comparative effects of EMG-driven robot-assisted therapy versus task-oriented training on motor and daily function in patients with stroke: a randomized cross-over trial.

Background: Robot-assisted hand training has shown positive effects on promoting neuromuscular control. Since both robot-assisted therapy and task-oriented training are often used in post-stroke rehabilitation, we raised the question of whether two interventions engender differential effects in different domains.

Methods: The study was conducted using a randomized, two-period crossover design.

Serum soluble programmed cell death 1 levels predict spontaneous functional cure in inactive carriers with chronic hepatitis B.

Background: Hepatitis B surface antigen (HBsAg) seroclearance is the most important milestone indicating favourable clinical outcomes in patients with chronic hepatitis B (CHB). However, it is difficult to achieve due to the impaired HBV-specific immunity, such as programmed cell death 1 (PD-1)-associated T cell exhaustion. We assessed soluble PD-1 (sPD-1) as a novel seromarker for predicting spontaneous HBsAg loss.

Identification of the novel HLA-C*07:446 allele in a volunteer bone marrow donor.

HLA-C*07:446 differs from HLA-C*07:02:01:01 by one nucleotide substitution at position 809 (C → T) in exon 4.

Characteristics and influencing factors of airborne microplastics in nail salons.

Airborne microplastic particles (MPs) are emerging contaminants. Although some studies have investigated the characteristics of indoor MPs in homes or offices, information regarding MPs in nail salons with potentially higher MP pollution is unavailable. In this study, we collected indoor and outdoor air samples from nail salons to analyze the concentrations, physical characteristics, and polymers of MPs and further assessed the exposure through inhalation and influencing factors.

Urate-lowering Therapy and Chronic Kidney Disease Development in Patients with Gout.

Chronic kidney disease (CKD) has emerged as a global health concern. Many studies have identified an association between hyperuricemia and CKD, and some studies have revealed that urate-lowering therapy (ULT) can attenuate CKD progression. However, only a few studies have explored the role of ULT in the prevention of new onset CKD.