Publications by authors named "Chia-Eng Wu"
Article Synopsis
- The study investigates how human pluripotent stem cells (hPSCs) can be developed into primordial germ cell-like cells (DDX4 PGCLCs) and potentially transformed into ovarian follicles to understand and treat infertility.
- Researchers found that DDX4 PGCLCs exhibit key characteristics of primitive germ cells and markers related to ovarian development.
- By co-culturing these cells with human granulosa cells, they successfully induced the formation of ovarian follicle-like structures in a mouse model, paving the way for future infertility treatments.
Objective: To study whether and how the pathogenesis of polycystic ovarian syndrome (PCOS) is related to epigenetic aberrations.
Design: A case-control experimental study.
Setting: Tertiary university hospital.
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and limited immunogenicity, as reflected by the reduced expression of major histocompatibility complex class-related molecules. Here we investigated the global immune-related gene expression profiles of human ESCs, hiPSCs and somatic cells and identified candidate immune-related genes that may alter their immunogenicity.
View Article and Find Full Text PDF