Publications by authors named "Chia-Chun Hou"
Article Synopsis
- Brain function plays a critical role in regulating aging and lifespan, with ongoing research to pinpoint specific brain regions involved.
- In Drosophila, the gene rab27 in the mushroom body neurons affects lifespan; depleting it in certain neurons can extend lifespan and improve stress responses without negative effects on overall function.
- The mechanism involves decreased protein synthesis and neuronal activity due to mislocalization of phosphorylated S6K, highlighting that inhibiting TOR signaling in these neurons can promote longevity.
Global heterochromatin reduction, which is one of the hallmarks of senescent cells, is associated with reduced transposable element repression and increased risk of chromatin instability. To ensure genomic integrity, the irreparable cells in a population exit permanently from the cell cycle, and this process is termed "senescence." However, senescence only blocks the expansion of unwanted cells, and the aberrant chromatin of senescent cells remains unstable.
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- MicroRNAs (miRNAs) are small RNA molecules that help regulate gene expression after genes are translated, playing a crucial role in metabolism and diseases like diabetes and obesity.
- miRNA-based therapies are being researched for their potential in improving diagnosis, treatment, and monitoring of metabolic disorders as well as serving as biomarkers for disease assessment.
- The text also discusses the promising role of miRNAs in stem cell therapy, suggesting their significant potential in the field of regenerative medicine.
The molecular and immunologic mechanisms associated with successful allergen-specific immunotherapy (ASIT) have not been completely elucidated. The aim of this study was to characterize the changes in Dermatophagoides farinae-specific IgG in atopic dogs undergoing ASIT using aqueous vaccines. Fifteen atopic dogs with a positive skin test reaction to D.
View Article and Find Full Text PDFA semiquantitative chemiluminescent Western blot analysis system was developed and validated to evaluate antigen-specific IgG subclass responses to electrophoretically separated proteins of Dermatophagoides farinae in healthy and atopic dogs. Both groups mounted similar D. farinae-specific IgG1 and IgG4 responses to multiple antigens, but IgG2 and IgG3 responses were difficult to detect.
View Article and Find Full Text PDFIgG responses to antigens from Dermatophagoides farinae in healthy and atopic dogs.
Vet Immunol Immunopathol
June 2005
In this study, we used a semi-quantitative electrophoresis and immunoblotting technique to characterise the IgG response to antigens from Dermatophagoides farinae in 20 healthy and 20 atopic dogs. Both groups mounted an IgG response to multiple antigens from the mite. There was no significant difference in the number of bands recognised, or the molecular weights of the bands, between the two groups.
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