Publications by authors named "Chia-Chi Kan"
Article Synopsis
- Mitochondrial DNA mutations, particularly the m.3243A>G mutation linked to MELAS, lead to Coenzyme Q (CoQ) deficiency, affecting mitochondrial function.
- The study found that mutant cybrids showed reduced energy production, impaired respiratory function, and lower CoQ levels compared to wild-type cybrids.
- Changes in gene expression and protein levels were observed in mutant cybrids, indicating disrupted mitochondrial energy pathways and differences in CoQ ratios compared to other mutations.
Background: The Coq protein complex assembled from several Coq proteins is critical for coenzyme Q6 (CoQ6) biosynthesis in yeast. Secondary CoQ10 deficiency is associated with mitochondrial DNA (mtDNA) mutations in patients. We previously demonstrated that carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) suppressed CoQ10 levels and COQ5 protein maturation in human 143B cells.
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