Publications by authors named "Chia-Chen Ko"
Article Synopsis
- Cervical spinal injuries disrupt blood pressure control, leading to potential cardiovascular issues, and while current guidelines recommend maintaining blood pressure with vasopressors, it may worsen spinal hemorrhage and injury.* -
- This study investigates whether the use of the vasopressor phenylephrine increases spinal hemorrhage and extravasation compared to saline in animal models, and assesses the impact of spinal decompression surgery.* -
- Results show that phenylephrine elevates blood pressure but worsens spinal damage, while spinal decompression surgery reduces the extent of hemorrhage and extravasation in treated animals.*
Quercetin, a flavonoid abundantly present in plants, is widely used as a phytotherapy in prostatitis and prostate cancer. Although quercetin has been reported to have a number of therapeutic effects, the cellular target(s) responsible for its anti-cancer action has not yet been clearly elucidated. Here, employing affinity chromatography and mass spectrometry, we identified heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) as a direct target of quercetin.
View Article and Find Full Text PDFIdentification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen.
Biochem Biophys Res Commun
January 2007
Article Synopsis
- * Among nearly 500 chemical compounds tested, MT4 was found to significantly reduce the release of TNF-alpha and IL-1beta, demonstrating effective anti-inflammatory properties with IC50 values of 22 nM and 44 nM, respectively.
- * The mechanism of MT4's action involves the inhibition of p38alpha and p38beta MAPK activity, with competitive binding to the ATP substrate site, indicating a potential target for treating chronic inflammation.