Prostaglandin E2 is activated by airway injury and regulates fibroblast cytoskeletal dynamics.

Objectives/hypothesis: To characterize the activation of cyclooxygenase (COX)-2/prostaglandin (PG) E2 signaling during airway mucosal repair and its subsequent role during the wound healing process.

Study Design: Prospective animal study.

Methods: The subglottis was approached via cricothyroidotomy.