Chelation-Tamoxifen Conjugates for Imaging of Estrogen Receptors.

The differential diagnosis of estrogen receptor-positive (ER+) pathway-activated systems by using a labeled antiestrogen helps to select the patients for optimal response to endocrine therapy and to discontinue the treatment when resistance occurs. The authors' purpose was to synthesize chelator-tamoxifen conjugates for imaging ER (+) diseases. A hydroxypropyl linker was incorporated between either cyclam or cyclam diacetic acid and tamoxifen analog to produce SC-05-L-1 (Z-1-(1,4,8,11-tetraazacyclotetradecan-1-yl)-3-((5-(4-(2-(diethylamino)ethoxy)phenyl)-4,5-diphenylpent-4-en-1-yl)oxy)propan-2-ol) and SC-05-N-1 (Z-2,2'-(4-(3-((5-(4-(2-(diethylamino)ethoxy)phenyl)-4,5-diphenylpent-4-en-1-yl)oxy)-2-hydroxy-propyl)-1,4,8,11-tetraazacyclotetradecane-1,8-diyl)diacetic acid), respectively.

Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging.

This article describes the design and synthesis of donor-bridge-acceptor-based semiconducting polymer dots (Pdots) that exhibit narrow-band emissions, ultrahigh brightness, and large Stokes shifts in the near-infrared (NIR) region. We systematically investigated the effect of π-bridges on the fluorescence quantum yields of the donor-bridge-acceptor-based Pdots. The Pdots could be excited by a 488 or 532 nm laser and have a high fluorescence quantum yield of 33% with a Stokes shift of more than 200 nm.

Dual Colorimetric and Fluorescent Imaging of Latent Fingerprints on Both Porous and Nonporous Surfaces with Near-Infrared Fluorescent Semiconducting Polymer Dots.

Semiconducting polymer dots (Pdots) have recently been proven as a novel type of ultrabright fluorescent probes that can be extensively used in analytical detection. Here, we developed a dual visual sensor based on Pdots for fingerprint imaging. We first designed and synthesized two types of near-infrared (NIR) fluorescent polymers and then embedded ninhydrin into the Pdot matrix.

Tuning the Emission of Semiconducting Polymer Dots from Green to Near-Infrared by Alternating Donor Monomers and Their Applications for in Vivo Biological Imaging.

Semiconducting polymer dots (Pdots) recently have emerged as a new class of extraordinarily bright fluorescent probes with promising applications in biological imaging and sensing. Herein multicolor semiconducting polymer nanoparticles (Pdots) were designed using benzothiadiazole (BT) as the acceptor, and various types of donors were incorporated to modulate their emission wavelengths. Specific cellular targeting and in vivo biotoxicity as well as microangiography imaging on zebrafish indicated these BT-based Pdots are promising candidates for biological applications.