The expression of nicotinic acetylcholine receptor subunits and their associations with local immune cells and prognosis in oral squamous cell carcinoma.

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that may be responsible for cancer cell proliferation, epithelial-mesenchymal transition (EMT), and immune regulation. However, little is known about the associations of different nAChR subunits with tumor microenvironment in oral squamous cell carcinoma (OSCC).

Methods: We retrospectively reviewed pathology samples from 75 OSCC patients by immunohistochemistry.

Treatment benefit of upfront autologous stem cell transplantation for newly diagnosed multiple myeloma: a systematic review and meta-analysis.

Background: Upfront high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) remains a profitable strategy for newly diagnosed multiple myeloma (MM) patients in the context of novel agents. However, current knowledge demonstrates a discrepancy between progression-free survival (PFS) and overall survival (OS) benefit with HDT/ASCT.

Methods: We conducted a systematic review and meta-analysis that included both randomized controlled trials (RCTs) and observational studies evaluating the benefit of upfront HDT/ASCT published during 2012 to 2023.

The expression and prognostic impact of proinflammatory cytokines and their associations with carcinogens in oropharyngeal squamous cell carcinoma.

In oropharyngeal squamous cell carcinoma (OPSCC), the relationships between immune responses, carcinogens, and prognoses are not clarified yet. Here, we retrospectively reviewed the pathology samples of 46 OPSCC patients, and used p16 to determine their human papillomavirus (HPV) status. The Cancer Genome Atlas (TCGA) database was also analyzed for further comparison.

The application of ultrasound in detecting lymph nodal recurrence in the treated neck of head and neck cancer patients.

Early detection of neck lymph node (LN) recurrence is paramount in improving the prognosis of treated head and neck cancer patients. Ultrasound (US) with US-guided fine needle aspiration (FNA) and core needle biopsy (CNB) have been shown to have great accuracy for LN diagnoses in the untreated neck. However, in the treated neck with fibrosis, their roles are not clarified.

Identifying the affected branches of vestibular nerve in vestibular neuritis.

Conclusion: The inner ear monitoring system is useful for identifying the affected branches of the vestibular nerve in cases of vestibular neuritis, providing insight about the interval for the relief of vertigo.

Objective: This study conducted an inner ear monitoring system including audiometry, and caloric, ocular vestibular evoked myogenic potential (oVEMP), and cervical VEMP (cVEMP) tests in cases of vestibular neuritis for assessing the affected branches of the vestibular nerve.

Methods: Twenty patients with vestibular neuritis underwent caloric, oVEMP, and cVEMP tests.

Ocular vestibular evoked myogenic potentials via bone-conducted vibrations applied to various midsagittal cranial sites.

Objective: This study applied bone-conducted vibration (BCV) stimulation to various midsagittal sites on the cranium to optimize stimulation conditions for ocular vestibular evoked myogenic potentials (oVEMPs).

Study Design: Ten healthy subjects (7 men and 3 women, aged 25-32 yr) without previous ear disorders were enrolled in this study. Each subject underwent oVEMP test using BCV applied to 4 cranial sites on the midsagittal plane, namely, the Fpz (above the glabella), Fz (the midline forehead at the hairline), Cz (vertex), and inion.