Publications by authors named "Chi-Ju Lee"
A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience.
G3 (Bethesda)
January 2021
Article Synopsis
- - Undergraduate students at UCLA conducted research using RNA interference (RNAi) and fluorescent proteins to pinpoint genes crucial for blood cell development in fruit flies, screening around 3,500 genes and finding 137 that affected hematopoiesis.
- - By targeting RNAi to different cell types involved in blood cell maturation, the researchers identified specific gene subsets that either facilitate or inhibit this process, revealing new insights into gene functions related to RNA processing and vesicular trafficking.
- - The CURE (Course-Based Undergraduate Research Experience) model not only enhanced students' understanding and skills in science but also improved retention rates in STEM fields, demonstrating the value of hands-on research in education.
Background: Diabetes disregulates inflammatory responses and impairs vascular function in wounds. Glucagon-like peptide-1 receptor (Glp-1R) agonists are hypoglycemic agents with pleiotropic vascular protective and anti-inflammatory effects. The therapeutic potential of a Glp-1 analogue in a diabetic rat model of excisional wound injury was investigated.
View Article and Find Full Text PDFPurpose: The purpose of this biomechanical study was to compare the ultimate failure strength, stiffness, cyclic displacement, and failure displacement of 5 different proximal biceps tenodesis fixation techniques, specifically comparing wedge tenodesis with the other 4 techniques.
Methods: Forty cadaveric shoulders underwent 1 of 5 long head of the biceps tenodesis techniques and were cyclically tested to failure by use of tensile forces applied parallel to the longitudinal axis of the humerus. A preload at 5 N was applied for 2 minutes, followed by cyclical loading for 500 cycles from 5 to 70 N at 1 Hz and a pull-to-failure test at 1 mm/s.