Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes.

Treatment of periodontitis in people with diabetes remains challenging. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1) in periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the production of reactive oxygen species (ROS) was elevated, while the expression of TRX1 was significantly reduced in the periodontal tissues of periodontitis mice with diabetes.

Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data.

Background: Periodontitis disease (PD) is associated with a systemic disorder of inflammatory bowel disease (IBD). The immune response is the common feature of the two conditions, but the more precise mechanisms remain unclear.

Methods: Differential expressed genes (DEGs) analysis and weighted gene co-expression network analysis (WGCNA) were performed on PD and Crohn's disease (CD) data sets to identify crosstalk genes linking the two diseases.

A Nanoconfined Water-Ion Coordination Network for Flexible Energy-Dissipation Devices.

Water-ion interaction in a nanoconfined environment that deeply constrains spatial freedoms of local atomistic motion with unconventional coupling mechanisms beyond that in a free, bulk state is essential to spark designs of a broad spectrum of nanofluidic devices with unique properties and functionalities. Here, it is reported that the interaction between ions and water molecules in a hydrophobic nanopore forms a coordination network with an interaction density that is nearly fourfold that of the bulk counterpart. Such strong interaction facilitates the connectivity of the water-ion network and is uncovered by corroborating the formation of ion clusters and the reduction of particle dynamics.

TRAF-STOP alleviates osteoclastogenesis in periodontitis.

The enhanced osteoclastogenesis contributes to alveolar bone resorption in periodontitis, which increases the risk of tooth loss. To reduce bone destruction, the inhibition of osteoclast development is proposed as a feasible treatment. CD40L-CD40-TRAF6 signal transduction plays a crucial role in inflammation, but how it regulates osteoclast activity in periodontitis has not been elucidated.

Tuning Proapoptotic Activity of a Phosphoric-Acid-Tethered Tetraphenylethene by Visible-Light-Triggered Isomerization and Switchable Protein Interactions for Cancer Therapy.

We herein report a phosphoric-acid-substituted tetraphenylethene (T-P) capable of adapting its geometric configuration and biological activity to the microenvironment upon light irradiation for apoptosis modulation. Different from most ultraviolet-responsive isomerization, T-P undergoes cis-trans isomerization under visible light irradiation, which is biocompatible and thus photo-modulation is possible in living biosystems. By using alkaline phosphatase (ALP) and albumin as dual targets, T-P isomers display different protein binding selectivity, cancer-cell internalization efficiency and apoptosis-inducing ability.

Characterization and RNA-seq transcriptomic analysis of a Scenedesmus obliqnus mutant with enhanced photosynthesis efficiency and lipid productivity.

Microalgae have received significant attention as potential next-generation microbiologic cell factories for biofuels. However, the production of microalgal biofuels is not yet sufficiently cost-effective for commercial applications. To screen higher lipid-producing strains, heavy carbon ion beams are applied to induce a genetic mutant.

Reconstructed Order Analysis-Based Vibration Monitoring under Variable Rotation Speed by Using Multiple Blade Tip-Timing Sensors.

On-line vibration monitoring is significant for high-speed rotating blades, and blade tip-timing (BTT) is generally regarded as a promising solution. BTT methods must assume that rotating speeds are constant. This assumption is impractical, and blade damages are always formed and accumulated during variable operational conditions.

Zincke's Salt-Substituted Tetraphenylethylenes for Fluorometric Turn-On Detection of Glutathione and Fluorescence Imaging of Cancer Cells.

In this paper, we report Zincke's salt-substituted tetraphenylethylenes 1a and 1b with Cl and PF as counteranions, respectively. The crystal structure of 1b was determined. Both 1a and 1b are almost nonemissive even in the aggregated states.

Introductory lecture: recent research progress on aggregation-induced emission.

Since the discovery of the aggregation-induced emission (AIE) phenomenon in 2001, research on AIE molecules has drawn much attention, and this area has been expanding tremendously. This brief review will focus on recent advances in the science and application of AIE molecules, including new mechanistic understanding, new AIE molecules for sensing and imaging, stimuli-responsive AIE molecules and applications of AIE molecules for OLEDs. Moreover, this review will give a perspective on the possible opportunities and challenges that exist in the future for this area.

Bio-/Chemosensors and Imaging with Aggregation-Induced Emission Luminogens.

Aggregation-induced emission (AIE) luminogens show abnormal fluorescent behavior; they are non-emissive in solution, but they become strongly emissive after aggregation. Sensing and imaging are the major applications of AIE luminogens. By properly manipulating the aggregation and deaggregation of AIE molecules, various bio-/chemosensors have been developed.

Highly solid-state emissive pyridinium-substituted tetraphenylethylene salts: emission color-tuning with counter anions and application for optical waveguides.

In this paper seven salts of pyridinium-substituted tetraphenylethylene with different anions are reported. They show typical aggregation-induced emission. Crystal structures of three of the salts with (CF(3)SO(2))(2) N(-), CF(3) SO(3)(-), and SbF(6)(-) as the respective counter anions, are determined.

Enhancing the activity and tuning the mechanism of formic acid oxidation at tetrahexahedral Pt nanocrystals by Au decoration.

Tetrahexahedral Pt nanocrystals (THH Pt NCs), bound by high index facets, belong to an emerging class of nanomaterials that promise to bridge the gap between model and practical electrocatalysts. The atomically stepped surfaces of THH Pt NCs are extremely active for the electrooxidation of small organic molecules but they also readily accommodate the dissociative chemisorption of such species, resulting in poisoning by strongly adsorbed CO. Formic acid oxidation is an ideal reaction for studying the balance between these competing catalyst characteristics, since it can proceed by either a direct or a CO mediated pathway.