Publications by authors named "Chi Ying Gary Ding"
A new cyclic decapeptide, trikoramide A (), has been isolated from samples of the marine cyanobacterium , collected from Bintan Island, Indonesia. Trikoramide A () is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data.
View Article and Find Full Text PDFCertain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins present in four environmental marine cyanobacterial samples collected from intertidal areas in Singapore. Based on 16S-ITS rRNA gene sequences, these filamentous cyanobacterial samples collected from Pulau Hantu were determined as , sp.
View Article and Find Full Text PDFArticle Synopsis
- Benderamide A is a cyclic depsipeptide found in a Singapore marine cyanobacterium, identified through bioassay-guided methods.
- Its structure was determined using various NMR techniques and mass spectrometry, with absolute configuration confirmed via Marfey's analysis and NOESY comparisons.
- Although it showed no antiproliferative effects on breast cancer cells, the presence of an amino acid change hints at reduced cytotoxicity; additional related compounds were identified for further study.