Publications by authors named "Chi W Huang"
Background: A commonly seen issue in facial palsy patients is brow ptosis caused by paralysis of the frontalis muscle powered by the frontal branch of the facial nerve. Predominantly, static methods are used for correction. Functional restoration concepts include the transfer of the deep temporal branch of the trigeminal nerve and cross-facial nerve grafts.
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- Recent studies indicate that andrographolide, a compound in Andrographis plants, may inhibit the NF-κB signaling pathway, contributing to its anti-inflammatory effects.
- This study found that andrographolide effectively reduced the expression of certain inflammatory markers and blocked the activation of NF-κB in rat vascular smooth muscle cells exposed to LPS and IFN-γ.
- The mechanism involves andrographolide activating ceramide production and protein phosphatase 2A (PP2A), leading to the dephosphorylation and inactivation of NF-κB, ultimately resulting in decreased inflammation in the cells.