Inhibition of Melanin Synthesis and Inflammation by Exosomes Derived from DB-14 Isolated from Flower.

is a lactic acid bacteria found in fermented products. In our previous study, was isolated from flowers, and its acid tolerance and antibacterial properties were thoroughly investigated. This study focuses on the inhibition of melanin synthesis and inflammation of exosomes derived from .

Single-cell mapping of regulatory DNA:Protein interactions.

Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibility and histone modifications. These complex networks have been shown to be disrupted during aging, disease, and cancer. However, profiling these networks across diverse cell types and states has been limited due to the technical constraints of existing methods for mapping DNA:Protein interactions in single cells.

First Report of Causing Fruit Rot on Hawthorn () in China.

Hawthorn () is an important economic fruit and Chinese medicinal plant, which is widely distributed in the northern China. In early July 2024, a fruit rot disease was observed on the young fruits of hawthorn in a park of Shouguang, Shandong Province, China (36°53'42.16″N, 118°47'22.

Determining the Recruiting Rate of Spontaneously Blinking Rhodamines by Density Functional Calculations.

A recruiting rate () of 0.1-5 s has been proposed as the criterion for super-resolution spontaneously blinking rhodamines. Accurate prediction of the recruiting rate () of rhodamines is very important for developing spontaneously blinking rhodamines.

Factors affecting the quality of postoperative rehabilitation in children with cochlear implants based on the theory of knowledge, attitude and practice.

Objectives: This study aimed to examine factors that influence postoperative rehabilitation outcomes in children with cochlear implants, using a knowledge-attitude-practice (KAP) framework.

Design: A total of 683 children with cochlear implants participated in this study. Hearing and speech assessments were conducted through face-to-face and/or telephone interviews, while parents' or guardians' KAP were assessed following detailed instructions provided beforehand.

Precise Control of Efficient Phosphorescence in Host-Guest Doping Systems via Dynamic Metal-Ligand Coordination.

Organic room-temperature phosphorescent (RTP) materials have wide-ranging applications in anticounterfeiting, biodiagnostics, and optoelectronic devices due to their unique properties. However, it remains a challenge to give organic RTP materials dynamic tunability to satisfy the demands of various advanced applications. Herein, we propose an effective strategy to precisely modulate phosphorescent performance by incorporating dynamic metal-ligand coordination within a host-guest doped system.

Arvimicrobium flavum gen. nov., sp. nov., A Novel Genus in the Family Phyllobacteriaceae Isolated From Forest Soil.

During the study of microbial diversity of forest soil in the Republic of Korea, a yellow pigment-producing, Gram-stain-negative, rod-shaped, motile bacterium was isolated and designated as strain 1W2. This strain grew at temperature of 10-37 °C, at pH of 5.0-9.

Residue behavior of imidacloprid FS formulation in peanut cultivation system in china and its dietary and ecological risk assessment.

Imidacloprid, a key neonicotinoid insecticide for pest control, is widely used in various crops, including peanuts. This study aimed to fill research gaps by analysing the residue behaviour of imidacloprid in peanut fields treated with flowable concentrate for seed treatment (FS) formulations while assessing potential risks to human health and ecosystems. A validated analytical method, using QuEChERS separation and UPLC-MS/MS detection, reliably quantified imidacloprid residues in peanuts and soil.

Metabolic Engineering of for Xylose Utilization from Cellulosic Biomass.

Cellulosic biomass hydrolysates are rich in glucose and xylose, but most microorganisms, including , are unable to utilize xylose effectively. To address this limitation, we engineered a strain optimized for xylose metabolism through the xylose oxidoreductase pathway and promoter optimization. A promoter library with varying strengths was used to fine-tune the expression levels of the , , and genes, resulting in a strain with a strong promoter for and weaker promoters for and .

High performers in the shadow: The adverse effect of star employees on their peers.

Star employees are pivotal to organizational success and significantly influence their peers. Previous studies on this topic often explore the attributes of stars and nonstars in isolation. Using social comparison theory, our study posits that as employees' performance approaches that of star employees, nonstar employees become more likely to compare themselves with stars, thereby increasing their sense of psychological entitlement.

Reversal of postoperative breast cancer metastasis by the use of embedded hydrogel.

Surgery is the primary treatment strategy for breast cancer (BC). However, postoperative recurrence is a great challenge faced by current surgical treatment strategies for BC. Therefore, it is worth studying how to prevent the recurrence of BC after surgery effectively.

Developing high-performance and sustainable polylactic acid/recycled polyolefin blends: Tuning the degree of functional group reaction and performance optimization.

In the current development of the plastics industry, the use of biodegradable and recycled plastics not only effectively reduces the volume of landfills and incineration but also significantly decreases environmental damage. However, the extensive application of biodegradable polylactic acid (PLA) is limited by its poor toughness and thermal properties. The study introduced recycled linear low-density polyethylene (R-LLDPE) and ethylene-octene copolymer (POE) to modify PLA, primarily based on their excellent toughness and thermal resistance.

Potential influence mechanism of mineral-organic matter (OM) interactions on the mobility of toxic elements in Pb/Zn smelter contaminated soils.

To date, how complex mineral-organic matter (OM) interactions affect the migration and mobility of potentially toxic elements (PTEs) in soils is highly understudied. This work mainly focused on the occurrence characteristics of PTEs and their close association with the composition characterization of mineral elements and dissolved OM (DOM) molecules. The results revealed that quartz (20.

Interfacial cfDNA Enrichment and Amplification with On-Chip Thermoplasmonics for Highly Sensitive Cancerous Liquid Biopsy.

Tumor-derived cell-free DNA (cfDNA) has been exploited as an effective liquid biopsy biomarker for early cancer diagnosis. However, the fragmented and low-abundance nature in circulating blood pose challenges for highly sensitive cfDNA quantification. Herein, a multifunctional plasmonic biosensor termed Interfacial cfDNA Enrichment, Amplification and Sensing with on-chip Thermoplasmonics (INEAST) is developed for cfDNA-based liquid biopsy and lung cancer diagnosis.

Mechanical stiffness across skin layers in human: a pilot study.

Mechanobiological forces play a pivotal role in the processes of skin homeostasis, wound healing and regeneration. Changes in tissue stiffness are linked to various skin diseases. Using atomic force microscopy, we analyzed the elastic modulus, representing mechanical stiffness, of different skin layers in a group of six participants, including 2 males and 4 females, aged between 1 and 70 years.

The Photophysics of Naphthalimide-Phenoselenazine Electron Donor-Acceptor Dyads: Revisiting the Heavy-Atom Effect in Thermally Activated Delayed Fluorescence.

We prepared thermally activated delayed fluorescence (TADF) emitter dyads, NI-PTZ, NI-PTZ-2Br and NI-PSeZ, with naphthalimide (NI) as electron acceptor and 10H-phenothiazine (PTZ) or 10H-phenoselenazine (PSeZ) as electron donor to study the heavy-atom effect on the intersystem crossing (ISC) and reverse ISC (rISC) in the TADF emitters. The delayed fluorescence lifetimes of the dyads containing heavy atoms ( =5.9 μs for NI-PSeZ and =16.

Engineering Saccharomyces boulardii for cell surface display of heterologous protein.

Saccharomyces boulardii and Saccharomyces cerevisiae share over 99 % genetic similarity yet exhibit distinct metabolic traits. While the cell surface display system of S. cerevisiae is well-documented, the equivalent system in S.

LcASR enhances tolerance to abiotic stress in Leymus chinensis and Arabidopsis thaliana by improving photosynthetic performance.

As a crucial forage grass, Leymus chinensis plays significant roles in soil and water conservation owing to its robust stress resistance. However, the underlying molecular mechanisms of its stress tolerance remain unclear. In this study, a novel gene, designated as LcASR (Abiotic Stress Resistance in Leymus chinensis), imparting resilience to both high light and drought, was identified.

A NIR-II emissive sonosensitized biotuner for pyroptosis-enhanced sonodynamic therapy of hypoxic tumors.

Pyroptosis is considered as a new way to effectively boost the immune response of tumors and inhibit tumor growth. Effective strategies to induce pyroptosis mainly rely on chemotherapeutic drugs and phototherapy, but their potential biotoxicity and phototoxicity limit their application in biomedicine. Herein, we designed a NIR-II emitting pyroptosis biotuner, Rd-TTPA, which induced pyroptosis under ultrasound irradiation to achieve pyroptosis-enhanced sonodynamic therapy (SDT) and immunogenic cell death (ICD) for tumors.

STAG2 promotes naive-primed transition via activating Lin28a transcription in mouse embryonic stem cells.

Mouse embryonic stem cells (mESCs) exist in two distinct pluripotent states: the naive and the primed. Mainly by inducing differentiation of mESCs in vitro, conducting RNA sequencing analyses, and specifying expression of the regulatory genes, we explored the regulatory mechanisms underlying the transition between the naive and primed states. We found that, under the defined differentiation-inducing conditions, the naive state of mESCs shifted to the primed state within 2 days of differentiation induction, during which the cell cycle- and differentiation-related proteins changes significantly.

Exposure-lag response of surface net solar radiation on lung cancer incidence: a global time-series analysis.

Background: Recently, the impact of solar radiation (RAD) on diseases worldwide has garnered growing attention. However, the association between RAD and lung cancer remains largely unknow and no consensus has been reached. The aim of this study was to investigate the lag exposure-response of RAD on lung cancer and provide robust scientific evidence for updating prevention and treatment strategies of lung cancer.