Prevalence of malnutrition among adult inpatients in China: a nationwide cross-sectional study.

Malnutrition substantially contributes to adverse clinical outcomes. However, no national survey has been conducted to characterize its epidemiology in hospital settings in China. We conducted the China Nutrition Fundamental Data 2020 project among a multistage stratified cluster sample of adult inpatients from 291 study sites across 30 provinces, autonomous regions and municipalities (except for Hong Kong, Macao, Taiwan Province, and the Xizang Autonomous Region, please see MATERIALS AND METHODS for details of the causes) of China to generate reliable data on the prevalence of malnutrition and explore the associated risk factors.

Phased characterization of soy protein gel modified by lactobacillus plantarum JYLP-326 in cooperation with acidic tremella fuciformis fruiting body polysaccharide: Focus on structural network, interaction and gel properties.

Soybean protein isolate (SPI) and acidic tremella fuciformis fruiting body polysaccharide (AP) were used to prepare phased products "sterilized soft gel (SPI-AP)" and "fermented strong gel (FSPI-AP)" to study the structural network, interaction and gel characteristics. The contents of α-helix (20.43 % to 25.

Forging-Submerged Arc Additive Hybrid Manufacturing of the Mn-Mo-Ni Component: In Situ Reheat Cycles Inducing the Homogenization of the HAZ Microstructure.

Forging additive hybrid manufacturing integrated the high efficiency of forging and the great flexibility of additive manufacturing, which has significant potential in the construction of reactor pressure vessels (RPVs). In the components, the heat-affected zone (HAZ, also called as bonding zone) between the forged substrate zone and the arc deposition zone was key to the final performance of the components. In this study, the Mn-Mo-Ni welding wire was deposited on the 16MnD5 substrate with a submerged arc heat source.

Arsenic Exposure Triggers Nonalcoholic Fatty Liver Disease through Repressing -Adenosylmethionine-Dependent Histone Methylation in Rats.

Arsenic (As) is a toxic metalloid widespread in the environment, and its exposure has been associated with a variety of adverse health outcomes. As exposure is demonstrated to cause nonalcoholic fatty liver disease (NAFLD), and the underlying epigenetic mechanisms remain largely unknown. This study aimed to investigate the roles of histone modifications in low-level As exposure-induced NAFLD in rats.

Proteomic analysis of effects of 1% atropine in myopia therapy in Guinea pigs.

Myopia is a significant global public health issue. Key interventions for managing myopia include atropine treatment, optical correction, and surgical methods. This study focused on evaluating alterations in retinal protein expression after atropine therapy for myopia.

STK11 mutation affects tumor proliferation by impacting CD4 T cell activity in lung adenocarcinoma.

Introduction: STK11 mutation is common in lung adenocarcinoma (LUAD), but the molecular mechanism of STK11 regulation in LUAD remains uncharacterized. This study intended to explore the effect of STK11 mutation on activity and proliferation of CD4 T cells in LUAD.

Material And Methods: qRT-PCR experiments verified the STK11 level in different cell models.

[Prokaryotic expression and purification of the transcription factor TaNAC14 in wheat ()].

The transcription factors (TFs) in the NAC family are involved in regulating multiple biological processes, playing an important role in plant growth, development, and stress adaptation. Our previous studies have demonstrated that TaNAC14, a member of the NAC family in wheat ( L.), positively regulates root growth and development and enhances the drought tolerance of wheat seedlings.

Leveraging AI technology for distinguishing Eucommiae Cortex processing levels and evaluating anti-fatigue potential.

Eucommiae Cortex (ECO) is a traditional medicinal and edible plant endemic to China, highly prized for its numerous health benefits. It typically undergoes special processing before application. The efficacy of ECO is influenced by processing techniques, necessitating the assurance of stability and consistency in its effects.

Brain tumor diagnosis in MRI scans images using Residual/Shuffle Network optimized by augmented Falcon Finch optimization.

Brain tumor diagnosis is an important task in prognosing and treatment planning of the patients with brain cancer. in the meantime, using the Magnetic Resonance Imaging (MRI) as a commonly used non-invasive imaging technique provide the experts a helpful view for detecting the brain tumors. While deep learning methods have shown significant success in analyzing medical images, they often require careful design of architecture and tuning of hyperparameters to achieve optimal results.

Genome Analysis of Gene Family and Function Exploration of in L.

The cyclic nucleotide-gated ion channel (CNGC), as a non-selective cation channel, plays a pivotal role in plant growth and stress response. A systematic analysis and identification of the gene family in is crucial for uncovering its biological functions and potential applications in plant science. In this study, we identified 61 members in the genome, which are phylogenetically similar to and can be classified into Groups I-IV (with Group IV further subdivided into IV-a and IV-b).

Effect of Interlayer Temperature on Microstructure and Properties of High-Strength Low-Alloy Steel Manufactured Using Submerged-Arc Additive Manufacturing (SAAM).

Controlled interlayer temperature has a profound impact on both the microstructure and mechanical properties of the deposited components. In this study, thin-walled structures made of high-strength low-alloy steel were fabricated using the submerged-arc additive manufacturing process. The effects of varying temperature on the microstructure and mechanical properties of the components were studied.

The study of Alzheimer's disease risk diagnosis based on natural killer cell marker genes in the multi-omics data.

Background: Alzheimer's disease (AD) is a common neurodegenerative disorder, currently lacking effective early diagnostic methods. However, natural killer (NK) cells may play a potential role in AD pathogenesis.

Objective: This study aims to identify AD-related feature genes from NK cell markers to construct a diagnostic model and explore their potential biological mechanisms in AD.

RBBP6-Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease.

Diabetic Kidney Disease (DKD), a major precursor to end-stage renal disease, involves mitochondrial dysfunction in proximal renal tubular cells (PTCs), contributing to its pathogenesis. Estrogen-related receptor α (ERRα) is essential for mitochondrial integrity in PTCs, yet its regulation in DKD is poorly understood. This study investigates ERRα expression and its regulatory mechanisms in DKD, assessing its therapeutic potential.

CCDC22 variants caused X-linked focal epilepsy and focal cortical dysplasia.

Background: The CCDC22 gene plays vital roles in regulating the NF-κB pathway, an essential pathway for neuroinflammation, neurodevelopment, and epileptogenesis. Previously, variants in CCDC22 were reported to be associated with intellectual disability. This study aimed to explore the association between CCDC22 and epilepsy.

Ccl5 Macrophages drive pro-inflammatory responses and neutrophil recruitment in sepsis-associated acute kidney injury.

Sepsis leads to dysfunctional immune responses with multi-organ damage, and acute kidney injury (AKI) is a common complication of sepsis. To gain a deeper understanding of the specific underlying mechanisms of sepsis, we investigated the effects of specific macrophages on sepsis. To gain a deeper understanding of the specific underlying mechanisms of sepsis, we investigated the effects of specific macrophages on sepsis.

Neurotransmitter metabolites in milk ferments of regulate temperature-sensitive heartbeats in an model.

Accumulated evidence has supported the probiotic activity of () which can yield beneficial metabolites via fermentation. Here, bovine milk rich in phenylalanine（PHE) was used as a source for fermentation of The complexes of PHE with bacterial phenylalanine hydroxylase (PheH) at two temperatures were revealed via molecular dynamics simulation. Two carbon hydrogen bonds and a Pi-Alkyl T-shaped interaction were newly formed at an active site of the PheH-PHE complex.

Non-targeted metabolomics and explainable artificial intelligence: Effects of processing and color on coniferyl aldehyde levels in Eucommiae cortex.

Eucommia ulmoides, a plant native to China, is valued for its medicinal properties and has applications in food, health products, and traditional Chinese medicine. Processed Eucommiae Cortex (EC) has historically been a highly valued medicine. Ancient doctors had ample experience processing EC, especially with ginger juice, as documented in traditional Chinese medical texts.

Single-cell RNA sequencing and spatial transcriptome reveal potential molecular mechanisms of lung cancer brain metastasis.

Background: Lung cancer is a highly aggressive and prevalent disease worldwide. By the time it is first diagnosed, distant metastases have usually already occurred. Among them, the prognosis of patients with brain metastasis from lung cancer is very poor.

Efficacy and Safety of High-Dose TBS on Poststroke Upper Extremity Motor Impairment: A Randomized Controlled Trial.

Background: Upper extremity (UE) motor function impairment is a major poststroke complication whose recovery remains one of the most challenging tasks in neurological rehabilitation. This study examined the efficacy and safety of the personalized neuroimaging-guided high-dose theta-burst stimulation (TBS) for poststroke UE motor function recovery.

Methods: Patients after stroke with UE motor impairment from a China rehabilitation center were randomly assigned to receive high-dose intermittent TBS (iTBS) to ipsilesional UE sensorimotor network, continuous TBS (cTBS) to contralesional UE sensorimotor network, or sham stimulation, along with conventional therapy for 3 weeks.

Lumican promotes calcific aortic valve disease through H3 histone lactylation.

Background And Aims: Valve interstitial cells (VICs) undergo a transition to intermediate state cells before ultimately transforming into the osteogenic cell population, which is a pivotal cellular process in calcific aortic valve disease (CAVD). Herein, this study successfully delineated the stages of VIC osteogenic transformation and elucidated a novel key regulatory role of lumican (LUM) in this process.

Methods: Single-cell RNA-sequencing (scRNA-seq) from nine human aortic valves was used to characterize the pathological switch process and identify key regulatory factors.