Effect of Hard-Segment Structure on the Properties of Polyurethane/Poly(Ethyl Methacrylate) Damping Composites.

Damping material performance influences the efficacy of vibration and noise reduction. However, traditional damping materials often have low damping peaks or narrow damping temperature ranges. In this study, a series of polyurethane (PU)/poly(ethylene methacrylate) (PEMA) composites were synthesised, in which the PU hard segments were varied using toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI), isophorone diisocyanate (IPDI), and hexamethylene diisocyanate.

Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. The combination of tremelimumab and durvalumab is now a standard treatment option for advanced HCC.

Objective: To study immune responses in HCC patients treated with tremelimumab and durvalumab.

Minimum maximum regularized multiscale convolutional neural network and its application in intelligent fault diagnosis of rotary machines.

Convolutional neural networks (CNN) have achieved significant advancements in intelligent fault diagnosis of rotary machines. However, the limitations of using a single scale convolution kernel in convolutional layer and the exclusive focus on classification accuracy by the cross-entropy loss function during model training result in suboptimal diagnostic performance and generalization ability of CNNs in environments with strong background noise and imbalanced data. To address these challenges, a fault recognition method for rotary machines utilizing a minimum maximum regularized multiscale CNN (MMRMCNN) is proposed.

Overlapping Clinical Phenotypes in Patients with Primary Ciliary Dyskinesia or Activated Phosphoinositide 3-Kinase Delta Syndrome.

Primary ciliary dyskinesia and activated phosphoinositide 3-kinase delta syndrome type 1 present similarly, with recurrent respiratory infections and reduced nasal nitric oxide levels. When diagnostic confirmation of primary ciliary dyskinesia with genetic testing and/or ciliary electron microscopy is inconclusive, activated phosphoinositide 3-kinase delta syndrome type 1 and other inborn errors of immunity must be investigated.

Regulating Interphase Chemistry by Targeted Functionalization of Hard Carbon Anode in Ester-Based Electrolytes for High-Performance Sodium-Ion Batteries.

Commercial hard carbon (HC) anode suffers from unexpected interphase chemistry rooted in the parasitic reactions between surface oxygen-functional groups and ester-based electrolytes. Herein, an innovative strategy is proposed to regulate interphase chemistry by tailoring targeted functional groups on the HC surface, where highly active undesirable oxygen-functional groups are skillfully converted into a Si-O-Si molecular layer favorable for anchoring anions. Then, an inorganic/organic hybrid solid electrolyte interphase with low interfacial charge transfer resistance and enhanced cycling durability is constructed successfully.

Bidirectional relationships between phonological processing and basic number knowledge in kindergarten children: a longitudinal study.

An ongoing debate on the association between phonological processing and number knowledge concerns the extent to which they influence each other during early childhood. The current study aims to establish the direction of the developmental relationship between these two kinds of abilities at an early age. Eighty-two Chinese kindergarten children were followed from 5 to 6 years old with a one-year interval.

Metallic PtC monolayer as a promising hydrogen evolution electrocatalyst.

Reasonable design of hydrogen evolution reaction (HER) electrocatalysts with low Pt loading and excellent catalytic performance is a key challenge in finding efficient and cost attractive catalysts. Pt with its unique d-electrons provides new opportunities for the development of HER catalysts when it forms compounds with highly earth-abundant C. Herein, we focused on designing highly efficient catalysts composed of Pt and C elements using first-principles structure search simulations, identifying four stability PtC monolayers.

Correlation between paraspinal muscle fat infiltration and thoracic vertebral degeneration based on phantom-less QCT: a novel insight into thoracic vertebral degeneration.

Purpose: This study aimed to elucidate the correlation between the degree of fat infiltration (FI) in thoracic paraspinal muscles and thoracic vertebral degeneration (TVD).

Methods: This cross-sectional study comprised 474 patients who underwent standard thoracic computed tomography (CT) scans. The FI was quantified as the percentage of adipose tissues within the cross-sectional area of thoracic paraspinal muscles.

Effects of Dietary Protein Levels on Digestion, Metabolism, Serum Biochemical Indexes, and Rumen Microflora of Lanzhou Fat-Tailed Sheep.

This study aimed to investigate the effect of varying levels of dietary protein on digestion, metabolism, serum biochemical indexes, and rumen microflora in Lanzhou fat-tailed sheep. A total of twenty 8-month-old healthy rams with an initial average body weight (BW 25.16 ± 1.

From Experimentation to Optimization: Surface Micro-Texturing for Low-Friction and Durable PTFE-Steel Interfaces Under Full Film Lubrication.

To enhance the sliding tribological performance between PTFE and 40#steel (AISI 1040) under full film lubrication conditions, laser surface texturing (LST) technology was employed to prepare micro-dimples on the contact surfaces of 40# steel discs. The Box-Behnken design response surface methodology (BBD-RSM) was applied to optimize the micro-dimple parameters. Coefficients of friction (COFs), wear losses and worn contact surfaces of the PTFE-40# steel tribo-pairs were researched through repeated wear tests, as lubricated with sufficient anti-wear hydraulic oil.

Transaxillary vs. Transsubclavian Gasless endoscopic thyroidectomy approaches for papillary thyroid cancer.

The use of transaxillary and transsubclavian approaches for endoscopic thyroidectomy has increased globally. However, studies examining the comparative outcomes of these procedures are scarce. In this study, we aimed to compare the safety and efficacy of thyroidectomy between the gasless endoscopic thyroidectomy transaxillary approach (GETTA) and gasless endoscopic thyroidectomy transsubclavian approach (GETTSA) in patients with papillary thyroid cancer (PTC).

Liver Cancer Neuroscience: Regulating Liver Tumors via Selective Hepatic Vagotomy.

Both the prevalence and mortality of liver cancers continue to rise. Early surgical interventions, including liver transplantation or resection, remain the only curative treatment. Nerves in the periphery influence tumor growth within visceral organs.

Regulating Carbon Vacancies and Undercoordinated Mo Sites in MoC Catalysts Toward Photo-Thermal Catalytic Conversion of Biomass Into H Fuel.

The conversion of biomass into chemical fuels is exciting but quite challenging in the development of an effective conversion strategy to generate easily-separated products without energy consumption. Herein, a lignocellulosic biomass-to-H conversion system via photo-thermal catalysis over MoC hierarchical nanotube catalysts in an acidic solution, in which the lignocellulose is hydrolyzed to small organic molecules (such as glucose, etc) by dilute HSO, and then the resulting glucose is oxidized by MoC catalyst to generate H are reported. During the photo-thermal catalytic processes, the carbon vacancy in MoC catalysts results in the generation of undercoordinated Mo sites, which act as active sites for both biomass oxidation and H generation reactions.

Multi-omics and network pharmacology approaches reveal Gui-Ling-Ji alleviates oligoasthenoteratozoospermia by regulating arachidonic acid pathway.

Background: Gui-Ling-Ji (GLJ) described in the ancient medical book 'Yunji Qijian' is a traditional Chinese medicine formula used to improve male fertility. It is now available for the treatment of oligoasthenoteratozoospermia (OAT). However, the active ingredients and mechanism of GLJ are not clear.

Protocol for establishing liver tumors via ultrasound-guided intrahepatic injection prior partial hepatic resection in a mouse model.

We present a protocol to generate a liver tumor murine model utilizing orthotopic ultrasound-guided intrahepatic injections of tumor cells and a partial hepatectomy. We describe cell and animal preparation and ultrasound-guided intrahepatic injections. We then depict how to conduct a partial hepatectomy addressing solutions to potential problems.

A Paradoxical Tumor Antigen Specific Response in the Liver.

Functional tumor-specific CD8+ T cells are essential for an effective anti-tumor immune response and the efficacy of immune checkpoint inhibitor therapy. In comparison to other organ sites, we found higher numbers of tumor-specific CD8+ T cells in primary, metastatic liver tumors in murine tumor models. Despite their abundance, CD8+ T cells in the liver displayed an exhausted phenotype.